Histone deacetylase inhibitor apicidin induces cyclin E expression through Sp1 sites
DC Field | Value | Language |
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dc.contributor.author | Soyoung Kim | - |
dc.contributor.author | Jae Ku Kang | - |
dc.contributor.author | Kim, Yong Kee | - |
dc.contributor.author | Dong-Wan Seo | - |
dc.contributor.author | Seong Hoon Ahn | - |
dc.contributor.author | Jae Cheol Lee | - |
dc.contributor.author | Chang-Hee Lee | - |
dc.contributor.author | Jueng-Soo You | - |
dc.contributor.author | Eun-Jung Cho | - |
dc.contributor.author | Hyang Woo Lee | - |
dc.contributor.author | Jeung-Whan Han | - |
dc.date.accessioned | 2022-04-19T08:57:16Z | - |
dc.date.available | 2022-04-19T08:57:16Z | - |
dc.date.issued | 2006-04 | - |
dc.identifier.issn | 0006-291X | - |
dc.identifier.issn | 1090-2104 | - |
dc.identifier.uri | https://scholarworks.sookmyung.ac.kr/handle/2020.sw.sookmyung/146266 | - |
dc.description.abstract | We show that a histone deacetylase (HDAC) inhibitor apicidin increases the transcriptional activity of cyclin E gene, which results in accumulation of cyclin E mRNA and protein in a time- and close-dependent manner. Interestingly, apicidin induction of cyclin E gene is found to be mediated by Sp1- rather than E21F-bincling sites in the cyclin E promoter, as evidenced by the fact that specific inhibition of Sp1 leads to a decrease in apicidin activation of cyclin E promoter activity and protein expression, but mutation of E2F-binding sites of cyclin E promoter region fails to inhibit the ability of apicidin to activate cyclin E transcription. In addition, this transcriptional activation of cyclin E by apicidin is associated with historic hyperacetylation of cyclin E promoter region containing Sp1-binding sites. Our results demonstrate that regulation of historic modification by an HDAC inhibitor apicidin contributes to induction of cyclin E expression and this effect is Sp1-dependent. (c) 2006 Elsevier Inc. All rights reserved. | - |
dc.format.extent | 6 | - |
dc.language | 영어 | - |
dc.language.iso | ENG | - |
dc.publisher | ACADEMIC PRESS INC ELSEVIER SCIENCE | - |
dc.title | Histone deacetylase inhibitor apicidin induces cyclin E expression through Sp1 sites | - |
dc.type | Article | - |
dc.publisher.location | 미국 | - |
dc.identifier.doi | 10.1016/j.bbrc.2006.02.081 | - |
dc.identifier.scopusid | 2-s2.0-33644883611 | - |
dc.identifier.wosid | 000236316100023 | - |
dc.identifier.bibliographicCitation | BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, v.342, no.4, pp 1168 - 1173 | - |
dc.citation.title | BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS | - |
dc.citation.volume | 342 | - |
dc.citation.number | 4 | - |
dc.citation.startPage | 1168 | - |
dc.citation.endPage | 1173 | - |
dc.description.isOpenAccess | N | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
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