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The dual effects of interleukin-18 in tumor progression
- Authors
- Park, Sunyoung; Cheon, Soyoung; Cho, Daeho
- Issue Date
- Oct-2007
- Publisher
- CHIN SOCIETY IMMUNOLOGY
- Keywords
- IL-18; Th1 immune response; NK cytotoxicity; tumor progression; immune escape
- Citation
- CELLULAR & MOLECULAR IMMUNOLOGY, v.4, no.5, pp 329 - 335
- Pages
- 7
- Journal Title
- CELLULAR & MOLECULAR IMMUNOLOGY
- Volume
- 4
- Number
- 5
- Start Page
- 329
- End Page
- 335
- ISSN
- 1672-7681
2042-0226
- Abstract
- Interleukin-18 (IL-18) was discovered as an interferon-gamma-inducing factor and had a critical role in inflammatory and immune response. It stimulates natural killer (NK) and T cells and enhances Th1 immune response. These activated immune cells eliminate cancer cells and virus-infected cells effectively. However, IL-18 has also been found to promote tumor progression. Higher expression or secretion level of IL-18 is detected in various cancer cells in comparison with normal control, and IL-18 is able to induce angiogenesis, migration/metastasis, proliferation and immune escape. These dual effects and the mechanism of IL-18 need to be investigated further as it relates to cancer.
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