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The dual effects of interleukin-18 in tumor progression

Authors
Park, SunyoungCheon, SoyoungCho, Daeho
Issue Date
Oct-2007
Publisher
CHIN SOCIETY IMMUNOLOGY
Keywords
IL-18; Th1 immune response; NK cytotoxicity; tumor progression; immune escape
Citation
CELLULAR & MOLECULAR IMMUNOLOGY, v.4, no.5, pp.329 - 335
Journal Title
CELLULAR & MOLECULAR IMMUNOLOGY
Volume
4
Number
5
Start Page
329
End Page
335
URI
https://scholarworks.sookmyung.ac.kr/handle/2020.sw.sookmyung/14632
ISSN
1672-7681
Abstract
Interleukin-18 (IL-18) was discovered as an interferon-gamma-inducing factor and had a critical role in inflammatory and immune response. It stimulates natural killer (NK) and T cells and enhances Th1 immune response. These activated immune cells eliminate cancer cells and virus-infected cells effectively. However, IL-18 has also been found to promote tumor progression. Higher expression or secretion level of IL-18 is detected in various cancer cells in comparison with normal control, and IL-18 is able to induce angiogenesis, migration/metastasis, proliferation and immune escape. These dual effects and the mechanism of IL-18 need to be investigated further as it relates to cancer.
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