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Anti-angiogenic, anti-inflammatory and anti-nociceptive activity of 4-hydroxybenzyl alcohol

Authors
Lim, Eun-JuKang, Hyun-JungJung, Hyun-JooPark, Eun-Hee
Issue Date
Sep-2007
Publisher
PHARMACEUTICAL PRESS-ROYAL PHARMACEUTICAL SOC GREAT BRITIAN
Citation
JOURNAL OF PHARMACY AND PHARMACOLOGY, v.59, no.9, pp 1235 - 1240
Pages
6
Journal Title
JOURNAL OF PHARMACY AND PHARMACOLOGY
Volume
59
Number
9
Start Page
1235
End Page
1240
URI
https://scholarworks.sookmyung.ac.kr/handle/2020.sw.sookmyung/14636
DOI
10.1211/jpp.59.9.0007
ISSN
0022-3573
2042-7158
Abstract
4-Hydroxybenzyl alcohol (HBA), one of the well-known phenolic compounds in diverse plants, displayed a significant inhibition in the chick chorioallantoic membrane (CAM) angiogenesis assay. HBA was shown to contain an anti-inflammatory activity in carrageenan-induced air pouch model in rats and acetic acid-induced permeability model in mice. Anti-nociceptive activity of HBA was also assessed using the acetic acid-induced writhing test in mice. HBA was able to suppress production of nitric oxide (NO) and expression of inducible nitric oxide synthase (iNOS) in lipopolysaccharide (LPS)-activated RAW264.7 macrophages. In the macrophages, the level of reactive oxygen species (ROS) was diminished by HBA. Taken together, HBA possesses anti-angiogenic, anti-inflammatory and anti-nociceptive activity possibly via its down-regulating activity on NO production, which may be partly responsible for the pharmacological efficacy of several folkloric medicines.
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