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Anti-angiogenic, anti-inflammatory and anti-nociceptive activity of 4-hydroxybenzyl alcohol

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dc.contributor.authorLim, Eun-Ju-
dc.contributor.authorKang, Hyun-Jung-
dc.contributor.authorJung, Hyun-Joo-
dc.contributor.authorPark, Eun-Hee-
dc.date.available2021-02-22T15:02:05Z-
dc.date.created2020-09-01-
dc.date.issued2007-09-
dc.identifier.issn0022-3573-
dc.identifier.urihttps://scholarworks.sookmyung.ac.kr/handle/2020.sw.sookmyung/14636-
dc.description.abstract4-Hydroxybenzyl alcohol (HBA), one of the well-known phenolic compounds in diverse plants, displayed a significant inhibition in the chick chorioallantoic membrane (CAM) angiogenesis assay. HBA was shown to contain an anti-inflammatory activity in carrageenan-induced air pouch model in rats and acetic acid-induced permeability model in mice. Anti-nociceptive activity of HBA was also assessed using the acetic acid-induced writhing test in mice. HBA was able to suppress production of nitric oxide (NO) and expression of inducible nitric oxide synthase (iNOS) in lipopolysaccharide (LPS)-activated RAW264.7 macrophages. In the macrophages, the level of reactive oxygen species (ROS) was diminished by HBA. Taken together, HBA possesses anti-angiogenic, anti-inflammatory and anti-nociceptive activity possibly via its down-regulating activity on NO production, which may be partly responsible for the pharmacological efficacy of several folkloric medicines.-
dc.language영어-
dc.language.isoen-
dc.publisherPHARMACEUTICAL PRESS-ROYAL PHARMACEUTICAL SOC GREAT BRITIAN-
dc.subjectP-HYDROXYBENZYL ALCOHOL-
dc.subjectGASTRODIA-ELATA BLUME-
dc.subjectNITRIC-OXIDE-
dc.subjectANTIOXIDANT-
dc.subjectCONSTITUENTS-
dc.subjectMACROPHAGES-
dc.subjectRHIZOMES-
dc.subjectCELLS-
dc.subjectRATS-
dc.subjectMICE-
dc.titleAnti-angiogenic, anti-inflammatory and anti-nociceptive activity of 4-hydroxybenzyl alcohol-
dc.typeArticle-
dc.contributor.affiliatedAuthorPark, Eun-Hee-
dc.identifier.doi10.1211/jpp.59.9.0007-
dc.identifier.scopusid2-s2.0-34548381799-
dc.identifier.wosid000249970600007-
dc.identifier.bibliographicCitationJOURNAL OF PHARMACY AND PHARMACOLOGY, v.59, no.9, pp.1235 - 1240-
dc.relation.isPartOfJOURNAL OF PHARMACY AND PHARMACOLOGY-
dc.citation.titleJOURNAL OF PHARMACY AND PHARMACOLOGY-
dc.citation.volume59-
dc.citation.number9-
dc.citation.startPage1235-
dc.citation.endPage1240-
dc.type.rimsART-
dc.type.docTypeArticle-
dc.description.journalClass1-
dc.description.journalRegisteredClassscie-
dc.description.journalRegisteredClassscopus-
dc.relation.journalResearchAreaPharmacology & Pharmacy-
dc.relation.journalWebOfScienceCategoryPharmacology & Pharmacy-
dc.subject.keywordPlusP-HYDROXYBENZYL ALCOHOL-
dc.subject.keywordPlusGASTRODIA-ELATA BLUME-
dc.subject.keywordPlusNITRIC-OXIDE-
dc.subject.keywordPlusANTIOXIDANT-
dc.subject.keywordPlusCONSTITUENTS-
dc.subject.keywordPlusMACROPHAGES-
dc.subject.keywordPlusRHIZOMES-
dc.subject.keywordPlusCELLS-
dc.subject.keywordPlusRATS-
dc.subject.keywordPlusMICE-
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