Anti-angiogenic, anti-inflammatory and anti-nociceptive activity of 4-hydroxybenzyl alcohol
DC Field | Value | Language |
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dc.contributor.author | Lim, Eun-Ju | - |
dc.contributor.author | Kang, Hyun-Jung | - |
dc.contributor.author | Jung, Hyun-Joo | - |
dc.contributor.author | Park, Eun-Hee | - |
dc.date.available | 2021-02-22T15:02:05Z | - |
dc.date.issued | 2007-09 | - |
dc.identifier.issn | 0022-3573 | - |
dc.identifier.issn | 2042-7158 | - |
dc.identifier.uri | https://scholarworks.sookmyung.ac.kr/handle/2020.sw.sookmyung/14636 | - |
dc.description.abstract | 4-Hydroxybenzyl alcohol (HBA), one of the well-known phenolic compounds in diverse plants, displayed a significant inhibition in the chick chorioallantoic membrane (CAM) angiogenesis assay. HBA was shown to contain an anti-inflammatory activity in carrageenan-induced air pouch model in rats and acetic acid-induced permeability model in mice. Anti-nociceptive activity of HBA was also assessed using the acetic acid-induced writhing test in mice. HBA was able to suppress production of nitric oxide (NO) and expression of inducible nitric oxide synthase (iNOS) in lipopolysaccharide (LPS)-activated RAW264.7 macrophages. In the macrophages, the level of reactive oxygen species (ROS) was diminished by HBA. Taken together, HBA possesses anti-angiogenic, anti-inflammatory and anti-nociceptive activity possibly via its down-regulating activity on NO production, which may be partly responsible for the pharmacological efficacy of several folkloric medicines. | - |
dc.format.extent | 6 | - |
dc.language | 영어 | - |
dc.language.iso | ENG | - |
dc.publisher | PHARMACEUTICAL PRESS-ROYAL PHARMACEUTICAL SOC GREAT BRITIAN | - |
dc.title | Anti-angiogenic, anti-inflammatory and anti-nociceptive activity of 4-hydroxybenzyl alcohol | - |
dc.type | Article | - |
dc.publisher.location | 영국 | - |
dc.identifier.doi | 10.1211/jpp.59.9.0007 | - |
dc.identifier.scopusid | 2-s2.0-34548381799 | - |
dc.identifier.wosid | 000249970600007 | - |
dc.identifier.bibliographicCitation | JOURNAL OF PHARMACY AND PHARMACOLOGY, v.59, no.9, pp 1235 - 1240 | - |
dc.citation.title | JOURNAL OF PHARMACY AND PHARMACOLOGY | - |
dc.citation.volume | 59 | - |
dc.citation.number | 9 | - |
dc.citation.startPage | 1235 | - |
dc.citation.endPage | 1240 | - |
dc.type.docType | Article | - |
dc.description.isOpenAccess | N | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Pharmacology & Pharmacy | - |
dc.relation.journalWebOfScienceCategory | Pharmacology & Pharmacy | - |
dc.subject.keywordPlus | P-HYDROXYBENZYL ALCOHOL | - |
dc.subject.keywordPlus | GASTRODIA-ELATA BLUME | - |
dc.subject.keywordPlus | NITRIC-OXIDE | - |
dc.subject.keywordPlus | ANTIOXIDANT | - |
dc.subject.keywordPlus | CONSTITUENTS | - |
dc.subject.keywordPlus | MACROPHAGES | - |
dc.subject.keywordPlus | RHIZOMES | - |
dc.subject.keywordPlus | CELLS | - |
dc.subject.keywordPlus | RATS | - |
dc.subject.keywordPlus | MICE | - |
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