Detailed Information

Cited 0 time in webofscience Cited 13 time in scopus
Metadata Downloads

Antitumor effect of soluble beta-1,3-glucan from Agrobacterium sp r259 KCTC 1019

Authors
Shim, Jung-HyunSung, Ki-JoongCho, Min-ChulChoi, Won-AYang, YoungLim, Jong-SeokYoon, Do-Young
Issue Date
Sep-2007
Publisher
KOREAN SOC MICROBIOLOGY & BIOTECHNOLOGY
Keywords
beta-1,3-Glucans; cytokine; adjuvant; antitumor; immune-stimulating activity
Citation
JOURNAL OF MICROBIOLOGY AND BIOTECHNOLOGY, v.17, no.9, pp.1513 - 1520
Journal Title
JOURNAL OF MICROBIOLOGY AND BIOTECHNOLOGY
Volume
17
Number
9
Start Page
1513
End Page
1520
URI
https://scholarworks.sookmyung.ac.kr/handle/2020.sw.sookmyung/14637
ISSN
1017-7825
Abstract
beta-1,3-Glucans enhance immune reactions such as antitumor, antibacterial, antiviral, anticoagulatory and wound healing activities. beta-1,3-Glucans have various functions depending on the molecular weight, degree of branching, conformation, water solubility, and intermolecular association. The molecular weight of the soluble glucan was about 15,000 as determined by a high-performance size exclusion chromatography. From the infrared (IR) and C-13 NMR analytical data, the purified soluble glucan was found to exclusively consist Of beta-D-glueopyranose with 1,3 linkage. We tested the immune-stimulating activities of the soluble beta-1,3-glucan extracted from Agrobocterium sp. R259 KCTC 10 19 and confirmed the following activities. IFN-gamma and each cytokines were induced in the spleens and thymus of mice treated with soluble beta-1,3-glucan. Adjuvant effect was observed on antibody production. Nitric oxide was synthesized in monocytic cell lines treated with beta-1,3-glucan. The cytotoxic and antitumor effects were observed on various cancer cell lines and ICR mice. These results strongly suggested that this soluble beta-1,3-glucan could be a good candidate for an immune-modulating agent.
Files in This Item
Go to Link
Appears in
Collections
이과대학 > 생명시스템학부 > 1. Journal Articles

qrcode

Items in ScholarWorks are protected by copyright, with all rights reserved, unless otherwise indicated.

Related Researcher

Researcher Yang, Young photo

Yang, Young
이과대학 (생명시스템학부)
Read more

Altmetrics

Total Views & Downloads

BROWSE