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The regulatory roles of motile cilia in CSF circulation and hydrocephalus

Authors
Kumar, VijayUmair, ZobiaKumar, ShivGoutam, Ravi ShankarPark, SoochulKim, Jaebong
Issue Date
7-Jul-2021
Publisher
BMC
Keywords
Cerebrospinal fluid; Cilia; Ependymal cells; Brain development; Ciliary motility; Brain ventricular system; Hydrocephalus; Ciliopathies
Citation
FLUIDS AND BARRIERS OF THE CNS, v.18, no.1, pp 1 - 11
Pages
11
Journal Title
FLUIDS AND BARRIERS OF THE CNS
Volume
18
Number
1
Start Page
1
End Page
11
URI
https://scholarworks.sookmyung.ac.kr/handle/2020.sw.sookmyung/146505
DOI
10.1186/s12987-021-00265-0
ISSN
2045-8118
Abstract
Background Cerebrospinal fluid (CSF) is an ultra-filtrated colorless brain fluid that circulates within brain spaces like the ventricular cavities, subarachnoid space, and the spine. Its continuous flow serves many primary functions, including nourishment, brain protection, and waste removal. Main body The abnormal accumulation of CSF in brain cavities triggers severe hydrocephalus. Accumulating evidence had indicated that synchronized beats of motile cilia (cilia from multiciliated cells or the ependymal lining in brain ventricles) provide forceful pressure to generate and restrain CSF flow and maintain overall CSF circulation within brain spaces. In humans, the disorders caused by defective primary and/or motile cilia are generally referred to as ciliopathies. The key role of CSF circulation in brain development and its functioning has not been fully elucidated. Conclusions In this review, we briefly discuss the underlying role of motile cilia in CSF circulation and hydrocephalus. We have reviewed cilia and ciliated cells in the brain and the existing evidence for the regulatory role of functional cilia in CSF circulation in the brain. We further discuss the findings obtained for defective cilia and their potential involvement in hydrocephalus. Furthermore, this review will reinforce the idea of motile cilia as master regulators of CSF movements, brain development, and neuronal diseases.
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