Therapeutic efficacy of DNA-loaded PLGA microspheres in tumor-bearing mice
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Son, Hye-Jung | - |
dc.contributor.author | Kim, Jin-Seok | - |
dc.date.available | 2021-02-22T15:02:24Z | - |
dc.date.issued | 2007-08 | - |
dc.identifier.issn | 0253-6269 | - |
dc.identifier.issn | 1976-3786 | - |
dc.identifier.uri | https://scholarworks.sookmyung.ac.kr/handle/2020.sw.sookmyung/14660 | - |
dc.description.abstract | In vivo gene therapy was attempted using poly-(D,L-lactic-co-glycolic. acid) microspheres containing the interleukin-12 gene (p2CMVmIL12) in colon adenocarcinoma (CT-26)-bearing Balb/ c mice. Treatment with IL-12-loaded microspheres inhibited tumor growth significantly compared to a control group treated with free IL-12 DNA, though the degree of tumor inhibition was not dependent on the amount of IL-12 gene loaded. Combining gene therapy with 5-fluorouracil (50 mg/kg) treatment further inhibited tumor growth compared with gene therapy alone. The results indicate that microsphere formulations of pDNA may provide an efficient gene delivery system. | - |
dc.format.extent | 4 | - |
dc.language | 영어 | - |
dc.language.iso | ENG | - |
dc.publisher | PHARMACEUTICAL SOC KOREA | - |
dc.title | Therapeutic efficacy of DNA-loaded PLGA microspheres in tumor-bearing mice | - |
dc.type | Article | - |
dc.publisher.location | 대한민국 | - |
dc.identifier.doi | 10.1007/BF02993975 | - |
dc.identifier.scopusid | 2-s2.0-34548713012 | - |
dc.identifier.wosid | 000249107600020 | - |
dc.identifier.bibliographicCitation | ARCHIVES OF PHARMACAL RESEARCH, v.30, no.8, pp 1047 - 1050 | - |
dc.citation.title | ARCHIVES OF PHARMACAL RESEARCH | - |
dc.citation.volume | 30 | - |
dc.citation.number | 8 | - |
dc.citation.startPage | 1047 | - |
dc.citation.endPage | 1050 | - |
dc.type.docType | Article | - |
dc.identifier.kciid | ART001264574 | - |
dc.description.isOpenAccess | N | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.description.journalRegisteredClass | kci | - |
dc.relation.journalResearchArea | Pharmacology & Pharmacy | - |
dc.relation.journalWebOfScienceCategory | Chemistry, Medicinal | - |
dc.relation.journalWebOfScienceCategory | Pharmacology & Pharmacy | - |
dc.subject.keywordPlus | INTRATUMORAL DELIVERY | - |
dc.subject.keywordPlus | PLASMID DNA | - |
dc.subject.keywordPlus | FORMULATION | - |
dc.subject.keywordAuthor | microsphere | - |
dc.subject.keywordAuthor | PLGA | - |
dc.subject.keywordAuthor | cancer gene therapy | - |
dc.subject.keywordAuthor | CT-26 | - |
dc.subject.keywordAuthor | 5-fluorouracil (5-FU) | - |
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