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Roles of lysine-specific demethylase 1 (LSD1) in homeostasis and diseases

Authors
Kim, DonghaKim, Keun IlBaek, Sung Hee
Issue Date
4-Jun-2021
Publisher
BMC
Keywords
Cancer; Hypoxia; Inflammation; Immunity; Neurodegenerative diseases
Citation
JOURNAL OF BIOMEDICAL SCIENCE, v.28, no.1, pp 1 - 14
Pages
14
Journal Title
JOURNAL OF BIOMEDICAL SCIENCE
Volume
28
Number
1
Start Page
1
End Page
14
URI
https://scholarworks.sookmyung.ac.kr/handle/2020.sw.sookmyung/146611
DOI
10.1186/s12929-021-00737-3
ISSN
1021-7770
1423-0127
Abstract
Lysine-specific demethylase 1 (LSD1) targets mono- or di-methylated histone H3K4 and H3K9 as well as non-histone substrates and functions in the regulation of gene expression as a transcriptional repressor or activator. This enzyme plays a pivotal role in various physiological processes, including development, differentiation, inflammation, thermogenesis, neuronal and cerebral physiology, and the maintenance of stemness in stem cells. LSD1 also participates in pathological processes, including cancer as the most representative disease. It promotes oncogenesis by facilitating the survival of cancer cells and by generating a pro-cancer microenvironment. In this review, we discuss the role of LSD1 in several aspects of cancer, such as hypoxia, epithelial-to-mesenchymal transition, stemness versus differentiation of cancer stem cells, as well as anti-tumor immunity. Additionally, the current understanding of the involvement of LSD1 in various other pathological processes is discussed.
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