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Epigenetic Targeting of Histone Deacetylases in Diagnostics and Treatment of Depression

Authors
Park, Hyun-SunKim, JongminAhn, Seong HoonRyu, Hong-Yeoul
Issue Date
May-2021
Publisher
MDPI
Keywords
histone deacetylase (HDAC); depression; biomarker; anti-depressant therapy
Citation
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, v.22, no.10, pp.1 - 16
Journal Title
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
Volume
22
Number
10
Start Page
1
End Page
16
URI
https://scholarworks.sookmyung.ac.kr/handle/2020.sw.sookmyung/146629
DOI
10.3390/ijms22105398
ISSN
1661-6596
Abstract
Depression is a highly prevalent, disabling, and often chronic illness that places substantial burdens on patients, families, healthcare systems, and the economy. A substantial minority of patients are unresponsive to current therapies, so there is an urgent need to develop more broadly effective, accessible, and tolerable therapies. Pharmacological regulation of histone acetylation level has been investigated as one potential clinical strategy. Histone acetylation status is considered a potential diagnostic biomarker for depression, while inhibitors of histone deacetylases (HDACs) have garnered interest as novel therapeutics. This review describes recent advances in our knowledge of histone acetylation status in depression and the therapeutic potential of HDAC inhibitors.
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