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Remote Switching of Elastic Movement of Decorated Ligand Nanostructures Controls the Adhesion-Regulated Polarization of Host Macrophages

Authors
Thangam, RamarKim, Myeong SooBae, GunhyuKim, YuriKang, NayeonLee, SungkyuJung, Hee JoonJang, JinhyeokChoi, HyojunLi, NaKim, MinjinPark, SangwooKim, Seong YeolKoo, Thomas MyeongseokFu, Hong EnJeon, Yoo SangAmbriovic-Ristov, AndrejaSong, Jae-JunKim, Soo YoungPark, SteveWei, QiangKo, ChanghyunLee, Ki-BumPaulmurugan, RamasamyKim, Young KeunKang, Heemin
Issue Date
May-2021
Publisher
WILEY-V C H VERLAG GMBH
Keywords
elastic ligand movement; macrophage adhesion; macrophage polarization; magnetic switching; nanoparticle decoration
Citation
ADVANCED FUNCTIONAL MATERIALS, v.31, no.21, pp 1 - 14
Pages
14
Journal Title
ADVANCED FUNCTIONAL MATERIALS
Volume
31
Number
21
Start Page
1
End Page
14
URI
https://scholarworks.sookmyung.ac.kr/handle/2020.sw.sookmyung/146653
DOI
10.1002/adfm.202008698
ISSN
1616-301X
1616-3028
Abstract
Design of materials with remote switchability of the movement of decorated nanostructures presenting cell-adhesive Arg-Gly-Asp ligand can decipher dynamic cell-material interactions in decorated ligand nanostructures. In this study, the decoration of ligand-bearing gold nanoparticles (ligand-AuNPs) on the magnetic nanoparticle (MNP) with varying ligand-AuNP densities is demonstrated, which are flexibly coupled to substrate in various MNP densities to maintain constant macroscopic ligand density. Magnetic switching of upward ("Upper Mag") or downward ("Lower Mag") movement of varying ligand-AuNPs is shown via stretching and compression of the elastic linker, respectively. High ligand-AuNP densities promote macrophage adhesion-regulated M2 polarization that inhibits M1 polarization. Remote switching of downward movement ("Lower Mag") of ligand-AuNPs facilitates macrophage adhesion-regulated M2 polarization, which is conversely suppressed by their upward movement ("Upper Mag"), both in vitro and in vivo. These findings are consistent with human primary macrophages. These results provide fundamental understanding into designing materials with decorated nanostructures in both high ligand-AuNP density and downward movement of the ligand-AuNPs toward the substrate to stimulate adhesion-regulated M2 polarization of macrophages while suppressing pro-inflammatory M1 polarization, thereby facilitating tissue-healing responses.
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첨단소재·전자융합공학부 (신소재물리전공)
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