Detailed Information

Cited 0 time in webofscience Cited 25 time in scopus
Metadata Downloads

Adrenocorticotropin hormone stimulates interleukin-18 expression in human HaCaT keratinocytes

Authors
Park, Hyun JeongKim, Hee JungLee, Jun YoungCho, Baik KeeGallo, Richard L.Cho, Dae Ho
Issue Date
May-2007
Publisher
ELSEVIER SCIENCE INC
Citation
JOURNAL OF INVESTIGATIVE DERMATOLOGY, v.127, no.5, pp 1210 - 1216
Pages
7
Journal Title
JOURNAL OF INVESTIGATIVE DERMATOLOGY
Volume
127
Number
5
Start Page
1210
End Page
1216
URI
https://scholarworks.sookmyung.ac.kr/handle/2020.sw.sookmyung/14696
DOI
10.1038/sj.jid.5700703
ISSN
0022-202X
1523-1747
Abstract
The hypothalamic-pituitary-adrenal (HPA) axis is activated by stress. This involves the production of corticotropin releasing hormone (CRH) with the subsequent release of proopiomelanocortin (POMC) peptides, of which adrenocorticotropin hormone (ACTH) is most important. Although the skin has the capacity to produce CRH and POMC peptides, the immunomodulatory roles of ACTH in skin are yet unknown. IL-18 has been known to affect cells involved in the inflammatory response. In this study, we aimed to identify the regulatory effect of ACTH on IL-18 expression of skin keratinocytes. Exposure of HaCaT cells to ACTH stimulated formation of IL-18 mRNA transcript and its protein products in a dose-dependent manner. Furthermore, we suggest that ACTH-induced IL-18 production is via the caspase-1 activation pathway, as IL-18 production induced by ACTH could be suppressed by caspase-1 inhibitor, and ACTH could increase caspase-1 activity. The effect of ACTH on IL-18 production was blocked by specific inhibitors of p38 kinase (SB203580) or extracellular signal-regulated kinase (ERK) (PD98059). In addition, ACTH-induced rapid phosphorylation of p38 kinase and ERK, and ACTH signaling occurred via melanocortin receptor 1 (MC1R) and receptor 2 (MC2R). These results suggest that ACTH stimulates IL-18 expression in human keratinocytes, which provides an insight into the interaction between ACTH and inflammatory mediators.
Files in This Item
There are no files associated with this item.
Appears in
Collections
대학 > 기초교양대학 > 기초교양학부 > 1. Journal Articles

qrcode

Items in ScholarWorks are protected by copyright, with all rights reserved, unless otherwise indicated.

Altmetrics

Total Views & Downloads

BROWSE