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Catechin-Bound Ceanothane-Type Triterpenoid Derivatives from the Roots of Zizyphus jujuba
- Authors
- Kang, KB (Kang, Kyo Bin); Kim, HW (Kim, Hyun Woo); Kim, JW (Kim, Jung Wha); Oh, WK (Oh, Won Keun); Kim, J (Kim, Jinwoong); Sung, SH (Sung, Sang Hyun)
- Issue Date
- Apr-2017
- Publisher
- AMER CHEMICAL SOC
- Keywords
- ZIZIPHUS-JUJUBA; CYCLOPEPTIDE ALKALOIDS; HEPATIC-INJURY; MILL.; FRUIT; PLANT
- Citation
- JOURNAL OF NATURAL PRODUCTS, v.80, no.4, pp 1048 - 1054
- Pages
- 7
- Journal Title
- JOURNAL OF NATURAL PRODUCTS
- Volume
- 80
- Number
- 4
- Start Page
- 1048
- End Page
- 1054
- ISSN
- 0163-3864
1520-6025
- Abstract
- Three unprecedented ceanothane-type triterpenoids, ent-epicatechinoceanothic acid A (1), ent-epicatechinoceanothic acid B (2), and epicatechino-3-deoxyceanothetric acid A (3), containing C-C bond linkages with catechin moieties, were isolated from the roots of Zizyphus jujuba. Their chemical structures, including absolute configurations, were established by spectroscopic analysis and calculation of their ECD spectra. A possible biogenetic pathway for C-C bond formation between the catechin and the triterpenoid moieties is presented. Compound 1 was evaluated for its antiproliferalive activity on HSC-T6 hepatic stellate cells.
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