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Inactivation of Mxi1 induces IL-8 secretion activation in polycystic kidney

Authors
Yoo, Kyung HyunSung, Young HoonYang, Moon HeeJeon, Jeong OkYook, Yeon JooWoo, Yu MiLee, Han-WoongPark, Jong Hoon
Issue Date
Apr-2007
Publisher
ACADEMIC PRESS INC ELSEVIER SCIENCE
Keywords
Mxi1; IL-8; polycystic kidney; inflammatory response; p38
Citation
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, v.356, no.1, pp 85 - 90
Pages
6
Journal Title
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
Volume
356
Number
1
Start Page
85
End Page
90
URI
https://scholarworks.sookmyung.ac.kr/handle/2020.sw.sookmyung/14701
DOI
10.1016/j.bbrc.2007.02.103
ISSN
0006-291X
1090-2104
Abstract
The Mxil proteins are biochemical and biological antagonists of c-myc oncoprotein. It has been reported that the overexpression pattern of c-myc might be similar to a molecular feature of early and late stages of human autosomal dominant polycystic kidney disease. We identified the cyst phenotype in Mxil-deficient mice aged 6-12 months using H&E staining. Some chemokines containing a protein domain similar to human IL-8, which is associated with the inflammatory response, were subsequently selected from the up-regulated genes. We confirmed the expression level of these chemokines and measured protein concentrations of IL-8 using ELISA in the Mxil-knockdown cells. IL-8 was found to be significantly increased in Mxil-knockdown cells. We found that p38 MAP kinase activation was involved in the signal transduction of the Mxil-inactivated secretion of IL-8. Therefore, we could suggest that the inactivation of Mxil leads to the inflammatory response and has the potential to induce polycystic renal disease. (c) 2007 Elsevier Inc. All rights reserved.
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