Inactivation of Mxi1 induces IL-8 secretion activation in polycystic kidney
- Authors
- Yoo, Kyung Hyun; Sung, Young Hoon; Yang, Moon Hee; Jeon, Jeong Ok; Yook, Yeon Joo; Woo, Yu Mi; Lee, Han-Woong; Park, Jong Hoon
- Issue Date
- Apr-2007
- Publisher
- ACADEMIC PRESS INC ELSEVIER SCIENCE
- Keywords
- Mxi1; IL-8; polycystic kidney; inflammatory response; p38
- Citation
- BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, v.356, no.1, pp 85 - 90
- Pages
- 6
- Journal Title
- BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
- Volume
- 356
- Number
- 1
- Start Page
- 85
- End Page
- 90
- URI
- https://scholarworks.sookmyung.ac.kr/handle/2020.sw.sookmyung/14701
- DOI
- 10.1016/j.bbrc.2007.02.103
- ISSN
- 0006-291X
1090-2104
- Abstract
- The Mxil proteins are biochemical and biological antagonists of c-myc oncoprotein. It has been reported that the overexpression pattern of c-myc might be similar to a molecular feature of early and late stages of human autosomal dominant polycystic kidney disease. We identified the cyst phenotype in Mxil-deficient mice aged 6-12 months using H&E staining. Some chemokines containing a protein domain similar to human IL-8, which is associated with the inflammatory response, were subsequently selected from the up-regulated genes. We confirmed the expression level of these chemokines and measured protein concentrations of IL-8 using ELISA in the Mxil-knockdown cells. IL-8 was found to be significantly increased in Mxil-knockdown cells. We found that p38 MAP kinase activation was involved in the signal transduction of the Mxil-inactivated secretion of IL-8. Therefore, we could suggest that the inactivation of Mxil leads to the inflammatory response and has the potential to induce polycystic renal disease. (c) 2007 Elsevier Inc. All rights reserved.
- Files in This Item
-
Go to Link
- Appears in
Collections - 이과대학 > 생명시스템학부 > 1. Journal Articles
Items in ScholarWorks are protected by copyright, with all rights reserved, unless otherwise indicated.