MG-63 cells proliferation following various types of mechanical stimulation on cells by auxetic hybrid scaffolds
- Authors
- Hong Jin Choi; Jun Jae Lee; Jung Bok Lee; Hak-Joon Sung; Jung-WoogShin; Ji Won Shin; Yan Ru Wu; 김정구
- Issue Date
- Dec-2016
- Publisher
- 한국생체재료학회
- Citation
- 생체재료학회지, v.20, no.4, pp 302 - 309
- Pages
- 8
- Journal Title
- 생체재료학회지
- Volume
- 20
- Number
- 4
- Start Page
- 302
- End Page
- 309
- URI
- https://scholarworks.sookmyung.ac.kr/handle/2020.sw.sookmyung/147013
- ISSN
- 1226-4601
2055-7124
- Abstract
- Background: Mechanical properties and cyto-compatibility of a composite scaffold which possessed negative (−) Poisson’s ratio (NPR) was investigated for effective load transfer from auxetic scaffold to cell. Methods: Organic/inorganic composite scaffolds were prepared by mixing hydroxyapatite (HA) to poly(lactide-coglycolide) (PLGA). To induce NPR in composite scaffold, 3-directional volumetric compression was applied during the scaffold fabrication at adequate temperature(60°C). The pore size of scaffold ranged between 355–400 μm. Results: Poisson’s ratios of NPR scaffolds and control scaffolds were −0.07 and 0.16 at 10 % strain. For stable physical stimulating to loaded cells, ceramic/polymer composite scaffold was prepared by incorporating HA in PLGA to increase mechanical strength. Compressive strength of the HA/PLGA composite scaffold (15 wt. % HA to PLGA) was about 21.7 % higher than that of PLGA-only scaffold. The recovery rates of the NPR composite scaffold after applying compression in the dry and wet states were 90 % and 60 %, respectively. Also the composite scaffold was shown to have better hydrophilicity (61.9°) compared to the PLGA-only scaffolds (65.3°). Cell proliferation of osteoblast-like cell line (MG-63) in the composite scaffold was 20 % higher than in PLGA-only scaffold at static compressiv
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