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An Implantable Wireless Interstitial Pressure Sensor With Integrated Guyton Chamber: in vivo Study in Solid Tumors

Authors
Song, SH (Song, Seung Hyun)Kim, A (Kim, Albert)Brown, M (Brown, Marcus)Jung, C (Jung, Chaeyong)Ko, S (Ko, S.)Ziaie, B (Ziaie, Babak)
Issue Date
Nov-2016
Publisher
IEEE-INST ELECTRICAL ELECTRONICS ENGINEERS INC
Citation
IEEE TRANSACTIONS ON BIOMEDICAL ENGINEERING, v.63, no.11, pp 2273 - 2277
Pages
5
Journal Title
IEEE TRANSACTIONS ON BIOMEDICAL ENGINEERING
Volume
63
Number
11
Start Page
2273
End Page
2277
URI
https://scholarworks.sookmyung.ac.kr/handle/2020.sw.sookmyung/147024
DOI
10.1109/TBME.2016.2522460
ISSN
0018-9294
1558-2531
Abstract
A wireless implantable interstitial fluid pressure (IFP) sensor with an integrated Guyton chamber is presented. This implantable device enables noninvasive and continuous measurements of IFP. The Guyton chamber allows for an accurate measurement of IFP without the interference from various cellular/tissue components. The sensor consists of a coil, an air chamber, a silicone membrane embedded with a nickel plate, and a Guyton chamber. The fabricated device is 3 mm in diameter and 1 mm in thickness. The sensor shows a linear response to the pressure with a sensitivity of 60 kHz/mmHg and a resolution of 1 mmHg. Experiments in human prostate cancer tumors grown in mice confirm the sensor's capability to operate in vivo and provide continuous wireless measurement of IFP, a surrogate parameter indicating the "window of opportunity" for delivering chemo-and radio-therapeutic agents.
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Song, Seung Hyun
첨단소재·전자융합공학부 (지능형전자시스템전공)
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