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Hypocholesterolemic Effects of the Cauliflower Culinary-Medicinal Mushroom, Sparassis crispa (Higher Basidiomycetes), in Diet-Induced Hypercholesterolemic Rats

Authors
Hong, KB (Hong, Ki Bae)Hong, SY (Hong, Sung-Yong)Joung, EY (Joung, Eun Young)Kim, BH (Kim, Byung Hee)Bae, SH (Bae, Song-Hwan)Park, Y (Park, Yooheon)Suh, HJ (Suh, Hyung Joo)
Issue Date
Oct-2015
Publisher
BEGELL HOUSE INC
Citation
INTERNATIONAL JOURNAL OF MEDICINAL MUSHROOMS, v.17, no.10, pp.965 - 975
Journal Title
INTERNATIONAL JOURNAL OF MEDICINAL MUSHROOMS
Volume
17
Number
10
Start Page
965
End Page
975
URI
https://scholarworks.sookmyung.ac.kr/handle/2020.sw.sookmyung/147111
DOI
10.1615/IntJMedMushrooms.v17.i10.60
ISSN
1521-9437
Abstract
The cauliflower culinary-medicinal mushroom, Sparassis crispa, possesses various biological activities that have been widely reported to have therapeutic applications. We examined the effects of S. crispa on serum cholesterol, hepatic enzymes related to cholesterol metabolism, and fecal sterol excretion in rats fed a cholesterol-rich diet for 4 weeks. Male Sprague-Dawley rats (8 weeks old) were randomly divided into 5 groups (n = 6 mice per group): normal diet (normal control [NC]), cholesterol-rich diet (cholesterol control [ CC]), cholesterol-rich diet plus S. crispa fruiting body (SC), cholesterol-rich diet plus S. crispa extract (SCE), and cholesterol-rich diet plus S. crispa residue (SCR). SCE supplementation significantly enhanced hepatic cholesterol catabolism through the upregulation of cholesterol 7 alpha-hydroxylase (CYP7A1) messenger RNA (mRNA) expression (2.55-fold compared with that in the NC group; P < 0.05) and the downregulation of 3-hydroxy-3-methylglutaryl coenzyme A (HMG-CoA) reductase mRNA expression (0.57-fold compared with that in the NC group; P < 0.05). Additionally, the SCE diet resulted in the highest fecal excretion of cholesterol and bile acid in hypercholesterolemic rats. In conclusion, mRNA expression of CYP7A1 and HMG-CoA reductase were significantly modulated by the absorption of
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생활과학대학 (식품영양학과)
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