Angiogenesis and vasculogenic mimicry as therapeutic targets in ovarian cancer
- Authors
- Lim, Dansaem; Do, Yeojin; Kwon, Byung Su; Chang, Woochul; Lee, Myeong-Sok; Kim, Jongmin; Cho, Jin Gu
- Issue Date
- Jun-2020
- Publisher
- KOREAN SOCIETY BIOCHEMISTRY & MOLECULAR BIOLOGY
- Keywords
- Angiogenesis; Ovarian cancer; Therapeutic target; Tumor vascularization; Vasculogenic mimicry
- Citation
- BMB REPORTS, v.53, no.6, pp 291 - 298
- Pages
- 8
- Journal Title
- BMB REPORTS
- Volume
- 53
- Number
- 6
- Start Page
- 291
- End Page
- 298
- URI
- https://scholarworks.sookmyung.ac.kr/handle/2020.sw.sookmyung/1472
- DOI
- 10.5483/BMBRep.2020.53.6.060
- ISSN
- 1976-6696
1976-670X
- Abstract
- Tumor angiogenesis is an essential process for growth and metastasis of cancer cells as it supplies tumors with oxygen and nutrients. During tumor angiogenesis, many pro-angiogenic factors are secreted by tumor cells to induce their own vascularization via activation of pre-existing host endothelium. However, accumulating evidence suggests that vasculogenic mimicry (VM) is a key alternative mechanism for tumor vascularization when tumors are faced with insufficient supply of oxygen and nutrients. VM is a tumor vascularization mechanism in which tumors create a blood supply system, in contrast to tumor angiogenesis mechanisms that depend on pre-existing host endothelium. VM is closely associated with tumor progression and poor prognosis in many cancels. Therefore, inhibition of VM may be a promising therapeutic strategy and may overcome the limitations of anti-angiogenesis therapy for cancer patients. In this review, we provide an overview of the current anti-angiogenic therapies for ovarian cancer and the current state of knowledge regarding the links between microRNAs and the VM process, with a focus on the mechanism that regulates associated signaling pathways in ovarian cancer. Moreover, we discuss the potential for VM as a therapeutic strategy against ovarian cancer.
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