Chitosan/Polyurethane Blended Fiber Sheets Containing Silver Sulfadiazine for Use as an Antimicrobial Wound Dressing
- Authors
- Lee, SJ; Heo, DN; Moon, JH; Park, HN; Ko, WK; Bae, MS; Lee, JB; Park, SW; Kim, EC; Lee, CH; Jung, BY; Kwon, IK
- Issue Date
- Oct-2014
- Publisher
- AMER SCIENTIFIC PUBLISHERS
- Keywords
- Antibiotic effect; Chitosan; Fiber sheets; Polyurethane; Silver sulfadiazine
- Citation
- JOURNAL OF NANOSCIENCE AND NANOTECHNOLOGY, v.14, no.10, pp 7488 - 7494
- Pages
- 7
- Journal Title
- JOURNAL OF NANOSCIENCE AND NANOTECHNOLOGY
- Volume
- 14
- Number
- 10
- Start Page
- 7488
- End Page
- 7494
- URI
- https://scholarworks.sookmyung.ac.kr/handle/2020.sw.sookmyung/147262
- DOI
- 10.1166/jnn.2014.9581
- ISSN
- 1533-4880
1533-4899
- Abstract
- Electrospun chitosan (CTS) nanofibers have been well known for use as a wound dressing in the biomedical field. Nevertheless, fatal bacterial infections are still a serious problem when CTS nanofibers are used for wound treatment. In this study, we designed a novel wound dressing based on blending the chitosan with polyurethane (CTS/PU) containing silver sulfadiazine (AgSD) in order to enhance both antibacterial activity and mechanical strength. This fiber sheet was produced using the electrospinning (ELSP) technique. The CTS/PU containing AgSD fiber sheet was characterized by energy-dispersive X-ray spectroscopy (EDX). The physicochemical properties of the CTS/PU/AgSD fiber sheets were also characterized by thermogravimetric analysis (TGA) and Fourier transform infrared spectroscopy (FT-IR). The electrospun fibers were morphologically characterized by scanning electron microscopy (SEM) and transmission electron microscopy (TEM). For an in vitro evaluation, the CTS/PU/AgSD fiber sheets were tested for their antibacterial activity against gram-negative Pseudomonas aeruginosa (P. aeruginosa), gram-positive Staphylococcus aureus (S. aureus) and Methicillin-resistant Staphylococcus aureus (MRSA). The results indicate that CTS/PU/AgSD fiber sheets have strong antimicrobial activity as displayed by inhibition of bacte
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