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MiR-193b and miR-365-1 are not required for the development and function of brown fat in the mouse

Authors
Feuermann, YonatanKang, KeunsooGavrilova, OksanaHaetscher, NadineJang, Seung JinYoo, Kyung HyunJiang, ChangtaoGonzalez, Frank JRobinson, Gertraud WHennighausen, Lothar
Issue Date
Dec-2013
Publisher
Landes Bioscience
Keywords
brown fat; miR-193b; mouse; gene knock-out; RNA-seq
Citation
RNA Biology, v.10, no.12, pp 1807 - 1814
Pages
8
Journal Title
RNA Biology
Volume
10
Number
12
Start Page
1807
End Page
1814
URI
https://scholarworks.sookmyung.ac.kr/handle/2020.sw.sookmyung/147396
DOI
10.4161/rna.27239
ISSN
1547-6286
1555-8584
Abstract
Generating heat and maintaining body temperature is the primary function of brown adipose tissue (BAT). Previous studies have implicated microRNAs, including miR-193b and miR-365-1, in BAT differentiation. We used mouse genetics to further understand the specific contributions of these two miRs. BAT function in mice with an inactivated miR-193b-365-1 locus, as determined by their response to the selective β3 adrenergic receptor agonist CL316.243 and their tolerance to cold exposure, was normal and expression of genes associated with functional BAT, including Prdm16 and Ucp1, was unaffected. In addition, genome-wide expression profiles of miRNAs and mRNAs in BAT in the presence and absence of miR-193b-365-1 were determined. In summary, these data demonstrate, in contrast to earlier work, that the development, differentiation, and function of BAT do not require the presence of miR-193b and miR-365-1. © 2013 Landes Bioscience.
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