Burn-Wound Healing Effect of Gelatin/PU Nanofiber Scaffold Containing Silver-Sulfadiazine
- Authors
- 허동녕; 양대혁; 이정복; 배민수; 김정호; 문호진; 전흥재; 김천호; 임호남; 권일근
- Issue Date
- Mar-2013
- Publisher
- American Scientific Publishers
- Citation
- Journal of Biomedical Nanotechnology, v.9, no.3, pp 511 - 515
- Pages
- 5
- Journal Title
- Journal of Biomedical Nanotechnology
- Volume
- 9
- Number
- 3
- Start Page
- 511
- End Page
- 515
- URI
- https://scholarworks.sookmyung.ac.kr/handle/2020.sw.sookmyung/147478
- DOI
- 10.1166/jbn.2013.1509
- ISSN
- 1550-7033
1550-7041
- Abstract
- Despite the fact that advances of burn treatment have led to reduction in the morbidity caused by burns, burn infection is still a serious problem. In this study, we designed blended synthetic and natural polymers nanofiber scaffolds using polyurethane (PU) and gelatin, which were prepared by an electrospinning method. Silver-sulfadiazine (SSD) was co-mixed to the blended polymer solution for being incorporated into the nanofibers after the electrospinning, followed by examination of burn-wound healing effect. The nanofiber scaffolds containing SSD should not only serve as a substrate for skin regeneration, but may also deliver suitable drugs, within a controlled manner during healing. The SSD release was able to prevent the growth of a wide array of bacteria and accelerate the wound healing by preventing infection. Therefore it could accelerate the burn-wound closure rate. We confirmed that PU/gelatin nanofiber scaffolds containing SSD lead to enhanced regeneration of burn-wounds.
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Collections - 이과대학 > 생명시스템학부 > 1. Journal Articles
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