ZrO2 surface chemically coated with hyaluronic acid hydrogel loading GDF-5 for osteogenesis in dentistry
- Authors
- 배민수; 김지은; 이정복; 허동녕; 양대혁; 김진호; 권긍록; 방재범; 배호재; 권일근
- Issue Date
- Jan-2013
- Publisher
- ELSEVIER SCI LTD
- Citation
- CARBOHYDRATE POLYMERS, v.92, no.1, pp 167 - 175
- Pages
- 9
- Journal Title
- CARBOHYDRATE POLYMERS
- Volume
- 92
- Number
- 1
- Start Page
- 167
- End Page
- 175
- URI
- https://scholarworks.sookmyung.ac.kr/handle/2020.sw.sookmyung/147504
- DOI
- 10.1016/j.carbpol.2012.09.044
- ISSN
- 0144-8617
- Abstract
- The objective of this study was to modify zirconium dioxide (ZrO2) with photo-cured hyaluronic acid hydrogel (pcHAgel), and to subsequently evaluate the bone regeneration potential of the modified ZrO2. In the present study, HA grafted onto a ZrO2 substrate was investigated for its biocompatibility and other properties. We describe the positive influences of ZrO2 surface-modified with pcHAgel (Zr-3) containing two different loads of growth and differentiation factor-5 (GDF-5) to aid new bone formation as compared to the same amount of BMP-2 (Zr-4–7). We characterized the Zr-3 for their surface morphology and chemical properties. Atomic force microscopy (AFM), scanning electron microscope (SEM), and X-ray photoelectron spectroscopy (XPS) showed that the pcHAgel was successfully grafted onto the ZrO2 surface. The sustained release of GDF-5 and BMP-2 were observed to occur in the Zr-4–7. In vitro cell tests showed a higher level of MG63 cell proliferation and differentiation on Zr-4–7 than on Zr-3. The Zr-3 is a good biomaterial to deliver osteogenic differentiation factors such as BMP-2 and GDF-5, and GDF-5 can be useful as an effective alternative to aid new bone formation as compared to BMP-2.
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