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BioVLAB-MMIA: A Cloud Environment for microRNA and mRNA Integrated Analysis (MMIA) on Amazon EC2

Authors
Lee, HyungroYang, YoungikChae, HeejoonNam, SeungyoonChoi, DonghoonTangchaisin, PatanachaiHerath, ChathuraMarru, SureshNephew, Kenneth P.Kim, Sun
Issue Date
Sep-2012
Publisher
IEEE-INST ELECTRICAL ELECTRONICS ENGINEERS INC
Keywords
Cloud computing; microRNAs; mRNAs; scientific workflows
Citation
IEEE TRANSACTIONS ON NANOBIOSCIENCE, v.11, no.3, pp 266 - 272
Pages
7
Journal Title
IEEE TRANSACTIONS ON NANOBIOSCIENCE
Volume
11
Number
3
Start Page
266
End Page
272
URI
https://scholarworks.sookmyung.ac.kr/handle/2020.sw.sookmyung/147583
DOI
10.1109/TNB.2012.2212030
ISSN
1536-1241
1558-2639
Abstract
MicroRNAs, by regulating the expression of hundreds of target genes, play critical roles in developmental biology and the etiology of numerous diseases, including cancer. As a vast amount of microRNA expression profile data are now publicly available, the integration of microRNA expression data sets with gene expression profiles is a key research problem in life science research. However, the ability to conduct genome-wide microRNA-mRNA (gene) integration currently requires sophisticated, high-end informatics tools, significant expertise in bioinformatics and computer science to carry out the complex integration analysis. In addition, increased computing infrastructure capabilities are essential in order to accommodate large data sets. In this study, we have extended the BioVLAB cloud workbench to develop an environment for the integrated analysis of microRNA and mRNA expression data, named BioVLAB-MMIA. The workbench facilitates computations on the Amazon EC2 and S3 resources orchestrated by the XBaya Workflow Suite. The advantages of BioVLAB-MMIA over the web-based MMIA system include: 1) readily expanded as new computational tools become available; 2) easily modifiable by re-configuring graphic icons in the workflow; 3) on-demand cloud computing resources can be used on an as needed basis; 4) distributed orch
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공과대학 (소프트웨어학부(첨단))
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