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Inhibition of bone resorption in cultures of mouse calvariae by apicularen A
- Authors
- Hong, JangJa; Sasaki, Hirokazu; Niikura, Kazuaki; Yanai, Maiko; Nakano, Yasuhiro; Yokomakura, Aya; Ishihara, Kenji; Hirasawa, Noriyasu; Kang, Young-Sook; Oh, Joa Sub; Kwak, Jong Hwan; Zee, OkPyo; Ohuchi, Kazuo
- Issue Date
- Feb-2007
- Publisher
- GEORG THIEME VERLAG KG
- Citation
- PLANTA MEDICA, v.73, no.2, pp 173 - 175
- Pages
- 3
- Journal Title
- PLANTA MEDICA
- Volume
- 73
- Number
- 2
- Start Page
- 173
- End Page
- 175
- ISSN
- 0032-0943
1439-0221
- Abstract
- Apicularens A and B were isolated from the myxobacterial genus Chondromyces apiculatus JW184. Apicularen A inhibited bafilomycin A1-sensitive ATP-dependent proton transport into microsome vesicles more potently than apicularen B. Bone resorption in cultures of mouse calvariae induced by human parathyroid hormone (PTH) or interleukin-1 beta (IL-1 beta) was inhibited by apicularen A at 10 and 100 nM, while apicularen B had no effect. The bisphosphonate incadronate inhibited bone resorption at 100 nM, being less effective than apicularen A. Our findings indicate that apicularen A inhibits bone resorption induced by PTH or IL-1 beta more potently than apicularen B, probably due to inhibition of the V-ATPase.
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