Photo-cured hyaluronic acid-based hydrogels containing simvastatin as a bone tissue regeneration scaffold
- Authors
- 배민수; 양대혁; 이정복; Dong Nyoung Heo; 권용대; 윤인찬; 최귀원; 홍종현; 김계태; 최용석; 황위환; 권일근
- Issue Date
- Nov-2011
- Publisher
- ELSEVIER SCI LTD
- Citation
- BIOMATERIALS, v.32, no.32, pp 8161 - 8171
- Pages
- 11
- Journal Title
- BIOMATERIALS
- Volume
- 32
- Number
- 32
- Start Page
- 8161
- End Page
- 8171
- URI
- https://scholarworks.sookmyung.ac.kr/handle/2020.sw.sookmyung/147736
- DOI
- 10.1016/j.biomaterials.2011.07.045
- ISSN
- 0142-9612
1878-5905
- Abstract
- We describe in this study the positive influences on in vitro and in vivo osteogenesis of photo-cured hyaluronic acid (HA) hydrogels loaded with simvastatin (SIM). Prior to loading SIM, we first characterized the HA hydrogels for their mechanical properties and swelling ratios. The results from this testing indicated that these two factors improved as the substitution degree of 2-aminoethyl methacrylate (AEMA) increased. MTT and live/dead assays showed that the HA hydrogels have good biocompatibility for use as scaffolds for bone tissue regeneration. Moreover, another MTT assay showed that the photo-cured HA hydrogels III fabricated with 30% AEMA (300 mg) conjugated HA (HA-AEMA iii) loaded with between 0.1 and 1 mg of SIM had a similar cytotoxicity as compared to the HA hydrogel III itself. The sustained release of SIM was observed to occur in the HA hydrogel III loaded with 1 mg of SIM. In vitro and in vivo experiments showed that the HA hydrogel III loaded with 1 mg of SIM had a significant influence on osteogenesis.
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