Poly(L-lactic acid) nanocylinders as nanofibrous structures for macroporous gelatin scaffolds
- Authors
- 이정복; 정성인; 배민수; 허동녕; 허정선; 황유식; 이현우; 권일근
- Issue Date
- Jul-2011
- Publisher
- American Scientific Publishers
- Citation
- INTERNATIONAL JOURNAL OF NANOTECHNOLOGY, v.11, no.7, pp 6371 - 6376
- Pages
- 6
- Journal Title
- INTERNATIONAL JOURNAL OF NANOTECHNOLOGY
- Volume
- 11
- Number
- 7
- Start Page
- 6371
- End Page
- 6376
- URI
- https://scholarworks.sookmyung.ac.kr/handle/2020.sw.sookmyung/147741
- DOI
- 10.1166/jnn.2011.4494
- ISSN
- 1533-4880
- Abstract
- Electrospun Nanofiber sheets have been shown to mimic the structure of extracellular matrix (ECM). Although these nanofibers have shown great potential for use as tissue engineering scaffolds, it is difficult for the electrospun nanofiber based sheets to be shaped into the desired three-dimensional structure. In this study, poly(L-lactic acid) (PLLA), a biodegradable and biocompatible polyester, was electrospun to produce nanofibers that were treated with an amino group containing base in order to fabricate polymeric nanocylinders. The aspect ratio of the PLLA nanocylinders was tunable by varying the aminolysis time and density of the amino group containing base. The effects of changes in nanofibrous morphology of the PLLA nanocylinders/macro-porous gelatin scaffolds on cell adhesion and proliferation were evaluated. The results revealed different cell morphology, adhesion, and proliferation in the nanocylinders composite gelatin scaffold versus gelatin scaffold alone. Confocal laser scanning microscopy observation showed more spreading and a more flattened cell morphology after NIH3T3 cells were cultured on PLLA nanocylinders/gelatin scaffolds for 10 hours and 4 days. These results indicate that the gelatin/PLLA nanocylinder composite is a promising way to fabricate 3D nanofibrous scaffolds that accelerates cell adhesion and proliferation for tissue engineering.
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