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Phospho-regulation of DDA3 function in mitosis

Authors
Jang, Chang-YoungCoppinger, Judith A.Yates III, John R.Fang, Guowei
Issue Date
Mar-2010
Publisher
Academic Press
Keywords
Chromosome congression; DDA3; Mitosis; Phosphorylation; Spindle
Citation
Biochemical and Biophysical Research Communications, v.393, no.2, pp 259 - 263
Pages
5
Journal Title
Biochemical and Biophysical Research Communications
Volume
393
Number
2
Start Page
259
End Page
263
URI
https://scholarworks.sookmyung.ac.kr/handle/2020.sw.sookmyung/147940
DOI
10.1016/j.bbrc.2010.01.115
ISSN
0006-291X
1090-2104
Abstract
DDA3 is a microtubule-associated protein that controls chromosome congression and segregation by regulating the mitotic spindle. Depletion of DDA3 alters spindle structure, generates unaligned chromosomes at metaphase, and delays the mitotic progression. Through a mass spectrometry analysis, we found that DDA3 is phosphorylated on Ser225 during mitosis. Phosphorylation of this residue is important for the mitotic function of DDA3, as the phospho-mimicking DDA3-S225D variant, but not the nonphosphorable DDA3-S225A mutant, rescues the DDA3-knockdown phenotype. We conclude that the mitotic function of DDA3 is regulated by phosphorylation on the Ser225 residue. © 2010 Elsevier Inc. All rights reserved.
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