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Effects of γ-irradiation on immunological activities of β-glucan
- Authors
- Jae-Hun Kim; Nak-Yun Sung; Eui-Hong Byun; Sun-Kyu Kwon; Beom-Seok Song; Jong-il Choi; Yohan Yoon; Jin-Kyu Kim; Myung-Woo Byun; Ju-Woon Lee
- Issue Date
- Oct-2009
- Publisher
- 한국식품과학회
- Keywords
- β-glucan; Depolymerization; Glycosidic bond; Immunological activity; Irradiation
- Citation
- Food Science and Biotechnology, v.18, no.5, pp 1305 - 1309
- Pages
- 5
- Journal Title
- Food Science and Biotechnology
- Volume
- 18
- Number
- 5
- Start Page
- 1305
- End Page
- 1309
- ISSN
- 1226-7708
- Abstract
- This study evaluated the effects of γ-irradiation on immunomodulating properties and structural changes of β-glucan. β-Glucan solutions (10 ㎎/㎖) were γ-irradiated at 10, 30, and 50 kGy. Splenocyte proliferation and cytokine (interferon-γ and interlukin-2) productions by γ-irradiated β-glucan were evaluated in in vivo and in vitro, and structural changes of β-glucan were also determined after γ-irradiation. γ-Irradiation on β-glucan at 50 kGy enhanced splenocyte proliferation and cytokine productions, (p＜0.05) and cleft glycosidic bonds of β-glucan resulting in lower the molecular weight. These results indicate that the use of γ-irradiation on β-glucan may be useful for improving its immunological activity by lowering the molecular weight of β-glucan.
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Collections - 생활과학대학 > 식품영양학과 > 1. Journal Articles
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