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한국인에서 CYP2A6 유전자다형과 흡연 및 SCE의 상관성 연구Association between the CYP2A6 Genetic Polymorphism and Smoking or Sister Chromatid Exchanges

Other Titles
Association between the CYP2A6 Genetic Polymorphism and Smoking or Sister Chromatid Exchanges
Authors
양미희
Issue Date
Jun-2007
Publisher
대한암예방학회
Keywords
CYP2A6; Genetic polymorphism; Smoking; SCE; CYP2A6; Genetic polymorphism; Smoking; SCE
Citation
대한암예방학회지, v.12, no.2, pp 75 - 78
Pages
4
Journal Title
대한암예방학회지
Volume
12
Number
2
Start Page
75
End Page
78
URI
https://scholarworks.sookmyung.ac.kr/handle/2020.sw.sookmyung/14804
ISSN
2288-3649
2288-3657
Abstract
The genetic polymorphism of cytochrome P450 (CYP) 2A6 has been emphasized to induce variations in smoking behavior, and in susceptibility to smoking-related cancer. However, there were a few studies concerning the CYP2A6 polymorphism in Korean populations. Therefore, focusing on presence of the CYP2A6 null allele (CYP2A6*4), I studied distribution of the CYP2A6 polymorphism in a Korean population (n=100) and its effects on sister chromatid exchange (SCE), a responsive biomarker for smoking or carcinogens. As results, the subjects who had the homozygous mutant type, the CYP2A6*4/*4, occupied 5.4% of the all subjects and most of them belonged to nonsmokers. However, the CYP2A6 polymorphism was not associated with the SCE levels (p=0.25), which were related to sex, smoking, and alcohol drinking. Therefore, presence of the CYP2A6 null allele may influence smoking behavior, however, it may be not involved in SCE-medicated cancer process. (Cancer Prev Res 12, 75-78, 2007)
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