Detailed Information

Cited 0 time in webofscience Cited 0 time in scopus
Metadata Downloads

Gamma irradiation reduces the immunological toxicity of doxorubicin, anticancer drug.

Authors
Jae-Hun KimNak-Yun SungH. Balaji RaghavendranYoon, Yo HanBeom-Seok SongJong-il ChoiYoung-Choon YooMyung-Woo ByunYoung-Jeong HwangJu-Woon Lee
Issue Date
Jul-2009
Publisher
PERGAMON-ELSEVIER SCIENCE LTD
Citation
RADIATION PHYSICS AND CHEMISTRY, v.78, no.7-8, pp 425 - 428
Pages
4
Journal Title
RADIATION PHYSICS AND CHEMISTRY
Volume
78
Number
7-8
Start Page
425
End Page
428
URI
https://scholarworks.sookmyung.ac.kr/handle/2020.sw.sookmyung/148086
DOI
10.1016/j.radphyschem.2009.03.020
ISSN
0969-806X
Abstract
Doxorubicin (DOX) is a widely used anticancer agent, but exhibits some immunological toxicity to patients during chemotherapy. The present study was conducted to evaluate the effect of gamma irradiation on the immunological response and the inhibition activity on in vivo tumor mass of DOX. The results showed that DOX irradiated at 10 and 20 kGy reduce the inhibition of mouse peritoneal macrophage proliferation and induce the release of cytokines (TNF-α and IL-6) when compared with non-irradiated DOX. The cytotoxicity against human breast (MCF-7), murine colon adenocarcinoma (Colon 26) and human monocytic (THP-1) tumor cell were not significantly different between non-irradiated and irradiated DOX (P<0.05). In vivo study on the tumor mass inhibition, gamma-irradiated DOX showed a considerable inhibition of tumor mass and this effect was statistically non-significant as compared with non-irradiated DOX. In conclusion, gamma irradiation could be regarded as a potential method for reducing the immunological toxicity of DOX. Further researches is needed to reveal the formation and activity of radiolysis products by gamma irradiation.
Files in This Item
Go to Link
Appears in
Collections
생활과학대학 > 식품영양학과 > 1. Journal Articles

qrcode

Items in ScholarWorks are protected by copyright, with all rights reserved, unless otherwise indicated.

Related Researcher

Researcher Yoon, Yo Han photo

Yoon, Yo Han
생활과학대학 (식품영양학과)
Read more

Altmetrics

Total Views & Downloads

BROWSE