Enhancement of cell survival by stromal cell-derived factor-1/CXCL12 involves activation of CREB and induction of Mcl-1 and c-Fos in factor-dependent human cell line MO7e
- Authors
- Joo, EK; Broxmeyer, HE; Kwon, HJ; Kang, HB; Kim, JS; Lim, JS; Choe, YK; Choe, IS; Myung, PK; Lee, Y
- Issue Date
- Oct-2004
- Publisher
- MARY ANN LIEBERT INC
- Citation
- STEM CELLS AND DEVELOPMENT, v.13, no.5, pp 563 - 570
- Pages
- 8
- Journal Title
- STEM CELLS AND DEVELOPMENT
- Volume
- 13
- Number
- 5
- Start Page
- 563
- End Page
- 570
- URI
- https://scholarworks.sookmyung.ac.kr/handle/2020.sw.sookmyung/148890
- DOI
- 10.1089/scd.2004.13.563
- ISSN
- 1547-3287
1557-8534
- Abstract
- Stromal cell-derived factor-1 (SDF-1/CXCL12) enhances the survival of hematopoietic stem and progenitor cells in synergy with other cytokines such as granulocyte-macrophage colony-stimulating factor (GM-CSF), steel factor, and thrombopoietin (TPO), and both the PI3K/Akt and MAPK pathways have been linked to this survival. To further evaluate intracellular signaling involved in SDF-1/CXCL12 survival effects, we investigated modulation of downstream signaling molecules. The synergistic survival enhancement of SDF-1/CXCL12 plus other cytokines were directly linked to enhanced phosphorylation of p70/85S6K and cAMP responsive element binding protein ( CREB), as well as enhanced induction of the Bcl-2 family member Mcl-1. Most prominently, c-Fos, a component of AP1 transcription factor, was synergistically induced by SDF-1/CXCL12 plus other cytokines. These results suggest that SDF-1/CXCL12 enhanced cell survival in synergy with other cytokines involves activation of CREB and induction of Mcl-1 and c-Fos.
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