B16F10 Murine Melanoma 세포에서 멜라닌생성억제에 대한 타우린의 효과Antimelanogenic Effect of Taurine in Murine Melanoma B16F10 Cells
- Other Titles
- Antimelanogenic Effect of Taurine in Murine Melanoma B16F10 Cells
- Authors
- 정효숙; 송경희; 김안근
- Issue Date
- Oct-2007
- Publisher
- 대한약학회
- Keywords
- taurine; ERK; MITF; tyrosinase; melanogenesis
- Citation
- 약 학 회 지, v.51, no.4, pp 350 - 354
- Pages
- 5
- Journal Title
- 약 학 회 지
- Volume
- 51
- Number
- 4
- Start Page
- 350
- End Page
- 354
- URI
- https://scholarworks.sookmyung.ac.kr/handle/2020.sw.sookmyung/14890
- ISSN
- 0377-9556
- Abstract
- the immune system. However, there is no study on the antimelanogenic effect of taurine. In this study, we investigated thewhitening effect of taurine in B16F10 mouse melanoma cells. Cell viability was measured by MTT assay. We examined mel-anin contents and tyrosinase activity according to time and concentration. Extracellular signal regulated kinase (ERK) is animportant regulator of melanogenesis. It has been reported that activated ERK induced microphthalmia asociated tran-scription factor (MITF) phosphorylation and its subsequent degradation and thus reduced melanin synthesis. In our B16F10cell culture system, taurine led to decrease melanin contents by 21% at 48 hr. We then observed taurine effects on ERK-P, MITF and tyrosinase by Western blot. ERK was activated at 18 hr and 24 hr, whereas MITF reduced. We could notobserve any differences in the levels of tyrosinase. These results suggested that taurine inhibited melanogenesis by ERKKeywords . taurine, ERK, MITF, tyrosinase, melanogenesis.... semiessential ....... ..... ....
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