햄스터 난소세포에서 Daidzein과 Genistein에 의해 유도된 산화적 스트레스에 대한 Vitamin C의 효과

Abstract

The oxidative stres causes many diseases like cancer, aging, cardiovascular disease, degenerative neurologicaldisorders (Parkinson's disease, and Alzheimer's disease) by damage of cell membrane, protein deformation, and damage ofDNA due to the oxidation of lipid of cell membrane, protein of tissue or enzyme, carbohydrate, and DNA. It is caused bythe reactive oxygen species (ROS) that is produced in the metabolic process of oxygen in cell. The superoxide dismutase(SOD), catalase (CAT), and glutathione peroxidase (GPx) in cell systemize the antioxidative enzymes to control the oxi-tein,activity of antioxidative enzyme, and ROS level, in order to study the effect of isoflavonoid over the ROS production in celland antioxidative system. As the similar action of the isoflavonoid with the estrogen is examined, women are encouragedto get bean. In view of this trend, it is very important to find out a combination medicine that lowers the oxidative strescaused by the daidzein in the ovarian cell. In the combined treatment of the typical antioxidant of vitamin C to oxidativestres which induced by daidzein recover the control level particularly lowering the ROS in cell by 30%. However, it madeno effect in the combined treatment with genistein. Therefore, the research tok the combination effect of daidzein withvitamin C in order to check it effect over the antioxidative system. In conclusion, it was disclosed that the oxidative stresC is related to the recovery of SOD activity.Keywords . daidzein, genistein, oxidative stress, vitamin C, antioxidant enzyme, hamster ovary cells