Synthesis of heteroarylpiperazines and heteroarylbipiperidines with a restricted side chain and their affinities for 5-HT1A receptor
DC Field | Value | Language |
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dc.contributor.author | Yoo K.H. | - |
dc.contributor.author | Choi H.S. | - |
dc.contributor.author | Kim D.C. | - |
dc.contributor.author | Shin K.J. | - |
dc.contributor.author | Kim D.J. | - |
dc.contributor.author | Song Y.S. | - |
dc.contributor.author | Jin C. | - |
dc.date.accessioned | 2022-04-19T12:03:54Z | - |
dc.date.available | 2022-04-19T12:03:54Z | - |
dc.date.issued | 2003-07 | - |
dc.identifier.issn | 0365-6233 | - |
dc.identifier.issn | 1521-4184 | - |
dc.identifier.uri | https://scholarworks.sookmyung.ac.kr/handle/2020.sw.sookmyung/149122 | - |
dc.description.abstract | Heteroarylpiperazine and heteroarylbipiperidine derivatives, bearing a 4-piperidine ring instead of an alkylamino side chain to give the semi-rigidity, were prepared and evaluated for their abilities to displace [3H] 8-OH-DPAT binding to the rat hippocampal synaptic membranes. These compounds showed low to moderate affinities for 5-HT1A receptor, with Ki values ranging from 6912 nM to 232 nM. Of these compounds, 8 b and 15 e exhibited the best affinities for 5-HT1A receptor with Ki values of 232 nM and 338 nM, respectively. | - |
dc.format.extent | 8 | - |
dc.language | 영어 | - |
dc.language.iso | ENG | - |
dc.publisher | John Wiley & Sons Ltd. | - |
dc.title | Synthesis of heteroarylpiperazines and heteroarylbipiperidines with a restricted side chain and their affinities for 5-HT1A receptor | - |
dc.type | Article | - |
dc.publisher.location | 미국 | - |
dc.identifier.doi | 10.1002/ardp.200300721 | - |
dc.identifier.scopusid | 2-s2.0-0042235082 | - |
dc.identifier.wosid | 000184659800002 | - |
dc.identifier.bibliographicCitation | Archiv der Pharmazie, v.336, no.4-5, pp 208 - 215 | - |
dc.citation.title | Archiv der Pharmazie | - |
dc.citation.volume | 336 | - |
dc.citation.number | 4-5 | - |
dc.citation.startPage | 208 | - |
dc.citation.endPage | 215 | - |
dc.description.isOpenAccess | N | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.subject.keywordAuthor | 5-HT1A receptor affinities | - |
dc.subject.keywordAuthor | Heteroarylbipiperidines | - |
dc.subject.keywordAuthor | Heteroarylpiperazines | - |
dc.subject.keywordAuthor | Restricted side chain | - |
dc.identifier.url | https://onlinelibrary.wiley.com/doi/10.1002/ardp.200300721 | - |
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