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Human rpS3 is involved in DNA repair and cell cycle controlHuman rpS3는 DNA repair와 cell cycle control에 관여한다

Other Titles
Human rpS3는 DNA repair와 cell cycle control에 관여한다
Authors
Hag Dong KimJang, Chang-YoungKimoon SeongHa-Chin SungJae Yung LeeByeong Jae LeeJoon Kim
Issue Date
Aug-2003
Publisher
Korean Society of Photoscience
Citation
Journal of Photoscience, v.10, no.2, pp 195 - 198
Pages
4
Journal Title
Journal of Photoscience
Volume
10
Number
2
Start Page
195
End Page
198
URI
https://scholarworks.sookmyung.ac.kr/handle/2020.sw.sookmyung/149127
ISSN
1225-8555
Abstract
In the cellular response to DNA damaging agents, cells undergo cell cycle arrest or apoptosis against irrepairable DNA damage. RpS3 is known to function as UV DNA repair endonuclease III and ribosomal protein S3. In this study, we used normal and rpS3-overexpressed 293T cells to examine the role of rpS3 in response to DNA damaging agents. When 293T cells transfected with rpS3 were irradiated with UV, the pattern of cell cycle was dramatically changed in comparison with un-transfected 293T cells. We also found that the expression of rpS3 in normal cells was increased by treatment with DNA damaging agents. By means of Western and Northern blot analyses in rat tissues, we showed the expression pattern of rpS3 protein and its mRNA. These data suggest that DNA repair and cell cycle arrest are interrelated to each other through rpS3, and the increased expression of rpS3 seems to regulate the cell cycle arrest by DNA damaging agents.
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