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생물학적 모니터링 데이터를 기초한 PBPK모델의 활용Application of Physiologically Based Pharmacokinetic Modeling with Biological Monitoring Data for Risk Assessment

Other Titles
Application of Physiologically Based Pharmacokinetic Modeling with Biological Monitoring Data for Risk Assessment
Authors
양미희양지연이빛나이호선
Issue Date
Mar-2007
Publisher
환경독성보건학회
Keywords
PBPK; biological monitoring; risk assessment; biomarker; exposure─ 1 ─※To whom correspondence should be addressed.Tel: +82-2-2077-7179; Fax: +82-2-710-9871E-mail: myang@sm.ac.kr나; 최근 식품 중 내분비계장애물질에 이르기까지다양한 영역에서 생물학적 모니터링이 요구되고있고 궁극적으로는 독성물질의 실제 노출에; PBPK; biological monitoring; risk assessment; biomarker; exposure─ 1 ─※To whom correspondence should be addressed.Tel: +82-2-2077-7179; Fax: +82-2-710-9871E-mail: myang@sm.ac.kr나; 최근 식품 중 내분비계장애물질에 이르기까지다양한 영역에서 생물학적 모니터링이 요구되고있고 궁극적으로는 독성물질의 실제 노출에
Citation
환경독성보건학회지, v.22, no.1, pp 1 - 8
Pages
8
Journal Title
환경독성보건학회지
Volume
22
Number
1
Start Page
1
End Page
8
URI
https://scholarworks.sookmyung.ac.kr/handle/2020.sw.sookmyung/14941
ISSN
2093-6400
Abstract
Biological monitoring, analyses of internal dose for exposure to toxicants, has been thought as one of thebest approaches for risk assessment. As the amount detected in human samples is generally very low, typicallyin the parts-per-bilion (ppb) or parts-per-trillion (ppt) range, analytic technologies such as HPLC, GC/MS,LC/MS, and LC/MS/MS have been continuously developed. In addition, route specific and sensitive exposurebiomarkers have been developed for proper biological monitoring. PBPK modeling, particularly reverse dosimetry, has been emphasized as an useful method via interpretationof biological monitoring results for regulation of toxicants. Thus, this review is focused on the use of PBPKdosimetry models for toxicology research and risk assessment in Korea.
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