국내 유전자치료 의약품 개발 및 평가시 고려해야 할 사항Points To Consider in Development and Evaluation of the Gene Therapy Products in Korea
- Other Titles
- Points To Consider in Development and Evaluation of the Gene Therapy Products in Korea
- Authors
- 김진석
- Issue Date
- Jun-2000
- Publisher
- 한국약제학회
- Citation
- 약제학회지, v.30, no.2, pp 139 - 143
- Pages
- 5
- Journal Title
- 약제학회지
- Volume
- 30
- Number
- 2
- Start Page
- 139
- End Page
- 143
- URI
- https://scholarworks.sookmyung.ac.kr/handle/2020.sw.sookmyung/149924
- ISSN
- 2093-5552
2093-6214
- Abstract
- Polyethylene glycol (PEG) is water soluble, biocompatible, non-toxic polymer and PEGylation is a well established technique for the modification of therapeutic proteins and peptides. PEG-protein drugs have been extensively studies in relation to therapies for various diseses: cancer, inflammation and others. The covalent attachment of PEG to proteins and peptides prolonged plasma half-life, reduced antigenicity and immunogenicity, increased thermal and mechanical stability, and prevented degradation by enzymes, Several chemical groups for general and site specific conjugation have been exploited to activate PEG for amino group, carboxyl group, and cysteine group. PEGylation of many proteins and peptides have been shown the difference in vivo stability and biological indicating that the site of PEG molecule attachment is one of the important factor to develop PEG-proteins as potential therapeutic agents.
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