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RASSF1A suppresses oncogenic H-Ras-induced c-Jun N-terminal kinase activation

Authors
Yoo, Young A.Na, Ah RamLee, Myeong-SokYoon, SukjoonKim, Jun SukYoo, Young Do
Issue Date
Dec-2006
Publisher
SPANDIDOS PUBL LTD
Keywords
RASSF1A; JNK; H-RaSG12V; p21(WAF1/CIP1); p27(Kip1)
Citation
INTERNATIONAL JOURNAL OF ONCOLOGY, v.29, no.6, pp 1541 - 1547
Pages
7
Journal Title
INTERNATIONAL JOURNAL OF ONCOLOGY
Volume
29
Number
6
Start Page
1541
End Page
1547
URI
https://scholarworks.sookmyung.ac.kr/handle/2020.sw.sookmyung/15037
DOI
10.3892/ijo.29.6.1541
ISSN
1019-6439
1791-2423
Abstract
The constitutive activation of JNK has been implicated in Ras-induced cellular transformation and activated JNK is down-regulated by the tumor suppressor protein, RASSF1A. In this study, we examined whether RASSF1A blocked oncogenic Ras-induced JNK activation. Exogenous expression of H-RaSG12V induced JNK phosphorylation and RASSF1A co-transfected with H-RaSG12V efficiently suppressed Ras-triggered JNK activation in various cancer cell lines. RASSF1A expression revived the H-Ras(G12V)-induced P27(Kip1) down-regulation. JNK siRNA treatment also promoted recovery from the H-Ras(G12V)-induced p27(Kip1) down-regulation. These results demonstrate that RASSF1A inhibited H-Ras(G12V)-induced JNK activation and JNK-mediated p27(Kip1) down-regulation. From these results, we propose that RASSFIA exerts a tumor-suppressing effect by blocking oncogenic Ras-induced JNK activation.
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