Detailed Information

Cited 0 time in webofscience Cited 0 time in scopus
Metadata Downloads

Determination of Multicomponent Dissolution Profiles of Pharmaceutical Products by in-situ Fiber-Optic UV Measurements

Authors
Gemperline, Paul J.Cho, JungHwanBaker, BrianBatchelor, BrianWalker, Dwight S.
Issue Date
Jun-1997
Publisher
Elsevier
Citation
Analytica Chimica Acta, v.345, no.1-3, pp 155 - 159
Pages
5
Journal Title
Analytica Chimica Acta
Volume
345
Number
1-3
Start Page
155
End Page
159
URI
https://scholarworks.sookmyung.ac.kr/handle/2020.sw.sookmyung/150493
DOI
10.1016/S0003-2670(97)00095-0
ISSN
0003-2670
1873-4324
Abstract
The feasibility of using a fiber-optic UV/visible spectrograph for in situ dissolution testing of a pharmaceutical product containing two active ingredients, sulfamethoxazole and trimethoprim, was demonstrated. Detailed dissolution profiles clearly showed that trimethoprim dissolved rapidly, while sulfamethoxazole dissolved slowly. Multivariate calibration of the fiber-optic spectrograph was accomplished using full-range spectra from 250 to 320 nm and principal component regress (PCR). Calibration mixtures were prepared from standard reference materials according to a three-level, central composite factorial design. It was not necessary to include excipients in the calibration mixtures. The accuracy of the new in situ UV/visible method was compared to a standard HPLC method and was limited to about ± 3% due to the high spectral similarity of the two active ingredients. The detailed dissolution profiles afforded by this new method may be an invaluable aid in the development of multicomponent, time-released drug products.
Files in This Item
Go to Link
Appears in
Collections
약학대학 > 약학부 > 1. Journal Articles

qrcode

Items in ScholarWorks are protected by copyright, with all rights reserved, unless otherwise indicated.

Related Researcher

Researcher Cho, Jung Hwan photo

Cho, Jung Hwan
약학대학 (약학부)
Read more

Altmetrics

Total Views & Downloads

BROWSE