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UVB-induced interleukin-18 production is downregulated by tannic acids in human HaCaT keratinocytes

Authors
Park, Hyun JeongKim, Hee JungKwon, Hyun JoLee, Jun YoungCho, Baik KeeLee, Wang JaeYang, YoungCho, Dae Ho
Issue Date
Aug-2006
Publisher
WILEY
Keywords
interleukin-18; tannic acids; ultraviolet B
Citation
EXPERIMENTAL DERMATOLOGY, v.15, no.8, pp 589 - 595
Pages
7
Journal Title
EXPERIMENTAL DERMATOLOGY
Volume
15
Number
8
Start Page
589
End Page
595
URI
https://scholarworks.sookmyung.ac.kr/handle/2020.sw.sookmyung/15099
DOI
10.1111/j.1600-0625.2006.00449.x
ISSN
0906-6705
1600-0625
Abstract
Tannic acids (TAs) are believed to be the key active components in plants, and are believed to be responsible for their anti-inflammatory, anti-viral effects and chemoprevention of cancer. However, the molecular mechanisms for the action of TA are unclear. This study examined the effects of TA on cutaneous inflammation with a human keratinocyte cell line (HaCaT). Interleukin-18 (IL-18) has multiple effects upon various cells involved in inflammatory response. In this study, the IL-18 mRNA expression and protein levels were reduced by a TA pretreatment. UV radiation can trigger the induction of the p38 mitogen-activated protein kinase (MAPK)-dependent signalling cascade. Immunoprecipitation and Western blot analysis was performed to determine if TA regulate the MAPK signalling pathway. TA significantly inhibited the activation of p38 MAPK and extracellular signal-regulated protein kinases. Moreover, TA-inhibited UVB enhanced the expression of the inflammatory mediators, IL-1, IL-6, tumor necrotic factor-alpha, cyclooxygenase-2 and prostaglandin E-2 in UVB-irradiated HaCaT cells. The topical application of TA on mouse skin treated with UVB irradiation has shown that TA inhibited the formation of erythema. These findings suggest that TA has significant anti-inflammatory effects on the UVB-induced response on the skin and may be a candidate natural compound for the regulation of cutaneous inflammation.
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대학 > 기초교양대학 > 기초교양학부 > 1. Journal Articles
이과대학 > 생명시스템학부 > 1. Journal Articles

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