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Liver PPAR alpha and UCP2 are involved in the regulation of obesity and lipid metabolism by swim training in genetically obese db/db mice

Authors
Oh, Ki SookKim, MinaLee, JinmiKim, Min JeongNam, Youn ShinHam, Jung EunShin, Soon ShikLee, Chung MooYoon, Michung
Issue Date
Jul-2006
Publisher
ACADEMIC PRESS INC ELSEVIER SCIENCE
Keywords
leptin receptor-null; obesity; PPAR alpha; swim training; UCP2
Citation
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, v.345, no.3, pp 1232 - 1239
Pages
8
Journal Title
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
Volume
345
Number
3
Start Page
1232
End Page
1239
URI
https://scholarworks.sookmyung.ac.kr/handle/2020.sw.sookmyung/15103
DOI
10.1016/j.bbrc.2006.04.182
ISSN
0006-291X
1090-2104
Abstract
Swim training for 6 weeks significantly decreased body weight gain, adipose tissue mass.. and adipocyte size in both sexes of genetically obese db/db mice compared with their respective sedentary controls. Swim training also caused significant decreases in serum levels of free fatty acids, triglycerides, and total cholesterol in both sexes of obese mice. Concomitantly, hepatic mRNA levels of peroxisome proliferator-activated receptor alpha (PPAR alpha) target enzymes responsible for mitochondrial and peroxisomal fatty acid P-oxidation were significantly increased by swim training. Moreover, mRNA levels of uncoupling protein 2 (UCP2) in liver were also markedly increased by swim training. In conclusion, these results suggest that swim training-induced transcriptional activation of hepatic PPAR alpha target enzymes and UCP2 may effectively prevent body weight gain, adiposity, and lipid disorders caused by leptin receptor deficiency in both sexes of mice. (c) 2006 Elsevier Inc. All rights reserved.
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