Detailed Information

Cited 0 time in webofscience Cited 51 time in scopus
Metadata Downloads

IL-18 enhances thrombospondin-1 production in human gastric cancer via JNK pathway

Authors
Kim, JihyeKim, CherlhyunKim, Tae SungBang, Sa IkYang, YoungPark, HyunjeongCho, Daeho
Issue Date
Jun-2006
Publisher
ACADEMIC PRESS INC ELSEVIER SCIENCE
Keywords
IL-18; TSP-1; gastric cancer; JNK pathway
Citation
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, v.344, no.4, pp 1284 - 1289
Pages
6
Journal Title
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
Volume
344
Number
4
Start Page
1284
End Page
1289
URI
https://scholarworks.sookmyung.ac.kr/handle/2020.sw.sookmyung/15114
DOI
10.1016/j.bbrc.2006.04.016
ISSN
0006-291X
1090-2104
Abstract
IL-18 is a pleiotropic cytokine that is produced by many cancer cells. A recent report suggested that IL-18 plays a key role in regulating the immune escape of melanoma and gastric cancer cells. Thrombospondin (TSP-1) is known to inhibit angiogenesis in several cancers but some studies have reported that it stimulates angiogenesis in some cancers such as gastric cancer. IL-18 and TSP-1 are related to tumor proliferation and metastasis. This study investigated the relationship between IL-18 and TSP-1 in gastric cancer. RT-PCR and ELISA showed that after the cells had been treated with IL-18, the level of TSP-1 mRNA expression and TSP-1 protein production by IL-18 increased in both a dose- and time-dependent manner. The cells were next treated with specific inhibitors in order to determine the signal pathway involved in IL-18-enhanced TSP-1 production. IL-18-enhanced TSP-1 expression was blocked by SP600125, a c-Jun N-terminal kinase (JNK) specific inhibitor. In addition, Western blot showed that IL-18 enhanced the expression of phosphorylated JNK. Overall, these results suggest that IL-18 plays a key role in TSP-1 expression involving JNK. (c) 2006 Elsevier Inc. All rights reserved.
Files in This Item
Go to Link
Appears in
Collections
대학 > 기초교양대학 > 기초교양학부 > 1. Journal Articles
이과대학 > 생명시스템학부 > 1. Journal Articles

qrcode

Items in ScholarWorks are protected by copyright, with all rights reserved, unless otherwise indicated.

Related Researcher

Researcher Yang, Young photo

Yang, Young
이과대학 (생명시스템학부)
Read more

Altmetrics

Total Views & Downloads

BROWSE