Nanotheranostics of Pre-Stenotic Vessels By Target Touch-On Signaling of Peptide Navigator
- Yu, Seung Eun; Chung, Seyong; Ha, Hyun-Su; Kim, Dae-Hyun; Baek, Sewoom; Kim, Tae Young; Lee, Songhyun; Yoon, Hyo-Jin; Chung, Soon Won; Lee, Jung Bok; Shin, Young Min; Kim, Hye-Seon; Kim, Si Young; Park, Joon-Sang; Kim, Chang-Soo; Sung, Hak-Joon
- Issue Date
- WILEY-V C H VERLAG GMBH
- CDK9; disturbed flow; nanotheranostics; pre-stenotic vessel; targeting peptide
- ADVANCED FUNCTIONAL MATERIALS, v.32, no.15, pp.1 - 13
- Journal Title
- ADVANCED FUNCTIONAL MATERIALS
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- End Page
- Navigation of nanoparticles to target sites of blood flow disturbance markedly upgrades the diagnostic paradigm in vascular medicine. The theranostic treatment of pre-stenotic vessels can prevent the irreversible occlusion process effectively. Here, these nanotheranostic functions are established by displaying CDK9(cyclin-dependent kinase 9)-targeting peptide (P.) onto nanovesicles (NV) and liposomes using the navigation function and subsequent binding-on signaling of P. as a game-changer. When rabbit vessels are allografted with injecting contrast-loaded P. liposomes, the case-dependent stenotic degree after 2-6 weeks can be diagnosed accurately within 2-4 days via computed tomography imaging with cross-validation in a mouse model of partial carotid ligation. Furthermore, the anti-CDK9 signaling of P. NV is activated post-targeting and effectively prevents vascular stenosis by suppressing inflammation and lipotoxicity in the vessels, serum, and/or liver. CDK9 targeting is confirmed using computer, in vitro, and in vivo models. This study demonstrates an unprecedented nanotheranostic function for future clinical applications.
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- 이과대학 > 생명시스템학부 > 1. Journal Articles
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