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Nanotheranostics of Pre-Stenotic Vessels By Target Touch-On Signaling of Peptide Navigator

Authors
Yu, Seung EunChung, SeyongHa, Hyun-SuKim, Dae-HyunBaek, SewoomKim, Tae YoungLee, SonghyunYoon, Hyo-JinChung, Soon WonLee, Jung BokShin, Young MinKim, Hye-SeonKim, Si YoungPark, Joon-SangKim, Chang-SooSung, Hak-Joon
Issue Date
Apr-2022
Publisher
WILEY-V C H VERLAG GMBH
Keywords
CDK9; disturbed flow; nanotheranostics; pre-stenotic vessel; targeting peptide
Citation
ADVANCED FUNCTIONAL MATERIALS, v.32, no.15, pp.1 - 13
Journal Title
ADVANCED FUNCTIONAL MATERIALS
Volume
32
Number
15
Start Page
1
End Page
13
URI
https://scholarworks.sookmyung.ac.kr/handle/2020.sw.sookmyung/151301
DOI
10.1002/adfm.202110368
ISSN
1616-301X
Abstract
Navigation of nanoparticles to target sites of blood flow disturbance markedly upgrades the diagnostic paradigm in vascular medicine. The theranostic treatment of pre-stenotic vessels can prevent the irreversible occlusion process effectively. Here, these nanotheranostic functions are established by displaying CDK9(cyclin-dependent kinase 9)-targeting peptide (P.) onto nanovesicles (NV) and liposomes using the navigation function and subsequent binding-on signaling of P. as a game-changer. When rabbit vessels are allografted with injecting contrast-loaded P. liposomes, the case-dependent stenotic degree after 2-6 weeks can be diagnosed accurately within 2-4 days via computed tomography imaging with cross-validation in a mouse model of partial carotid ligation. Furthermore, the anti-CDK9 signaling of P. NV is activated post-targeting and effectively prevents vascular stenosis by suppressing inflammation and lipotoxicity in the vessels, serum, and/or liver. CDK9 targeting is confirmed using computer, in vitro, and in vivo models. This study demonstrates an unprecedented nanotheranostic function for future clinical applications.
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