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Synthesis and biological activity of [[(heterocycloamino)alkoxy] benzyl]-2,4-thiazolidinediones as PPAR gamma agonists
- Issue Date
- May-2006
- Publisher
- PHARMACEUTICAL SOCIETY KOREA
- Keywords
- benzothiazole; thiazolidinediones; PPAR gamma; nitric oxide; diabetes
- Citation
- ARCHIVES OF PHARMACAL RESEARCH, v.29, no.5, pp 394 - 399
- Pages
- 6
- Journal Title
- ARCHIVES OF PHARMACAL RESEARCH
- Volume
- 29
- Number
- 5
- Start Page
- 394
- End Page
- 399
- ISSN
- 0253-6269
1976-3786
- Abstract
- Benzothiazole derivatives of thiazolidinediones (TZD) were synthesized using a modified Mitsunobu reaction of 2-(benzothiazol-2-ylmethylamino)ethanol (2) with 5-(4-hydroxybenzyl)-3triphenylmethylthiazolidine-2,4-dione and assayed for activity on peroxisome proliferator-activated receptor (PPAR) subtypes and inhibitory activity of NO production in lipopolysaccharide-activated macrophages. Most of the tested compounds were identified as potent PPAR7 agonists, indicating their potential as drug candidates for diabetes.
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