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The Immunomodulatory Effect of β-Glucan Depends on the Composition of the Gut Microbiotaopen access

Authors
Sung, M.Yoon, Y.Lee, J.
Issue Date
Sep-2023
Publisher
Multidisciplinary Digital Publishing Institute (MDPI)
Keywords
gut microbiota composition; health-functional food; immunomodulatory effect; β-glucan
Citation
Foods, v.12, no.17
Journal Title
Foods
Volume
12
Number
17
URI
https://scholarworks.sookmyung.ac.kr/handle/2020.sw.sookmyung/151596
DOI
10.3390/foods12173148
ISSN
2304-8158
2304-8158
Abstract
This study aimed to elucidate the relationship between the immunomodulatory effects of β-glucan and the composition of gut microbiota in mice. The mice were fed a diet containing β-glucan for 3 weeks, and feces, blood, and tissues were then collected to analyze the immunomodulatory effect and gut microbiota composition. Based on the results of the analysis of the expression level of immune-associated proteins, the high immunomodulatory effect group (HIE) and low immunomodulatory effect group (LIE) were categorized. Before the β-glucan diet, the proportions of the phylum Bacteroidota, family Muribaculaceae, and family Lactobacillaceae were significantly higher in HIE than in LIE. Furthermore, the genus Akkermansia was absent before the β-glucan diet and increased after β-glucan diet. These microbes had the ability to metabolize β-glucan or were beneficial to health. In conclusion, our findings demonstrate that variation in the composition of gut microbiota among individuals can result in varying expressions of β-glucan functionality. This outcome supports the notion that β-glucan may be metabolized through diverse pathways by gut microbes originally possessed by mice, subsequently producing various metabolites, such as short-chain fatty acids. Alternatively, the viscosity of the intestinal mucosa could be enhanced by β-glucan, potentially promoting the growth of certain bacteria (e.g., the genus Akkermansia). This study provides insights into the intricate interplay between β-glucan, gut microbiota, and immunomodulation. © 2023 by the authors.
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