Detailed Information

Cited 0 time in webofscience Cited 40 time in scopus
Metadata Downloads

T lymphocytes and dendritic cells are activated by the deletion of peroxiredoxin II (Prx II) gene

Authors
Moon, EYNoh, YWHan, YHKim, SUKim, JMYu, DYLim, JS
Issue Date
Feb-2006
Publisher
ELSEVIER SCIENCE BV
Keywords
peroxiredoxin II (Prx II); reactive oxygen species (ROS); dendritic cell; T lymphocyte
Citation
IMMUNOLOGY LETTERS, v.102, no.2, pp 184 - 190
Pages
7
Journal Title
IMMUNOLOGY LETTERS
Volume
102
Number
2
Start Page
184
End Page
190
URI
https://scholarworks.sookmyung.ac.kr/handle/2020.sw.sookmyung/15179
DOI
10.1016/j.imlet.2005.09.003
ISSN
0165-2478
1879-0542
Abstract
Peroxiredoxin II (Prx II) is a member of antioxidant enzyme family and it plays a protective role against oxidative damage. Constitutive production of endogenous reactive oxygen species was detected in spleen and bone marrow cells lacking Prx II. Here, we investigated the role of Prx II in immune responses. The total number of splenocytes (especially, the population of S-phase cells and CD3(+) T cells) was significantly higher in Prx II-/- mice than in wild type. Number of peripheral blood mononuclear cells (PBMCs) in Prx II-/- mice was also higher than wild type. Differentiation of Prx II-/- mouse bone marrow cells into CDIIc-positive dendritic cells was greater than that of wild type. Transplantation of Prx II-/- bone marrow cells into wild type mice increased PBMCs in blood and bone marrow-derived dendritic cells. Prx II deletion enhances concanavalin A (ConA)-induced splenocyte proliferation and mixed lymphocyte reaction (MLR) activity of bone marrow-derived CDIIc-positive dendritic cells to stimulate recipient splenocytes. Collectively, these data suggest that Prx II inhibits the immune cell responsiveness, which may be regulated by scavenging the low amount of reactive oxygen species (ROS). (c) 2005 Elsevier B.V. All rights reserved.
Files in This Item
There are no files associated with this item.
Appears in
Collections
이과대학 > 생명시스템학부 > 1. Journal Articles

qrcode

Items in ScholarWorks are protected by copyright, with all rights reserved, unless otherwise indicated.

Related Researcher

Researcher Lim, Jong Seok photo

Lim, Jong Seok
이과대학 (생명시스템학부)
Read more

Altmetrics

Total Views & Downloads

BROWSE