Novel pH sensitive block copolymer micelles for solvent free drug loading
- Authors
- Shim, WS; Kim, SW; Choi, EK; Park, HJ; Kim, JS; Lee, DS
- Issue Date
- Feb-2006
- Publisher
- WILEY-V C H VERLAG GMBH
- Keywords
- block copolymers; micelle-unimer transition; pH sensitive micelles; self-assembly; solvent free drug loading
- Citation
- MACROMOLECULAR BIOSCIENCE, v.6, no.2, pp 179 - 186
- Pages
- 8
- Journal Title
- MACROMOLECULAR BIOSCIENCE
- Volume
- 6
- Number
- 2
- Start Page
- 179
- End Page
- 186
- URI
- https://scholarworks.sookmyung.ac.kr/handle/2020.sw.sookmyung/15181
- DOI
- 10.1002/mabi.200500182
- ISSN
- 1616-5187
1616-5195
- Abstract
- Novel pH sensitive biodegradable block copolymers (MPEG-PDLLA-OSM) composed of mono-methoxy poly(ethylene glycol) (MPEG), poly (D,L-lactide) (PDLLA) and sulfamethazine oligomer (OSM) were synthesized via ring-opening polymerization and a dicyclohexyl carboimide (DCC) coupling reaction. These copolymers had a relatively low critical micelle concentration (CMC) due to the strong hydrophobic properties of non-ionized OSM at pH 7.0. Also, the pH sensitive block copolymers showed the micelle-unimer transition due to the ionization-non-ionization of OSM in the pH range (pH 7.2-8.4) above the CMC. Due to the pH sensitive properties of the block copolymer, the hydrophobic drug paclitaxel (PTX) was incorporated into a pH sensitive block copolymer micelle by the pH induced micellization method, without using an organic solvent. The block copolymer micelle prepared by pH induced micellization showed a relatively high PTX loading efficiency, and good stability for 2 d at 37 degrees C. Furthermore, the PTX loaded micelle showed a sustained release of PTX with a small burst in vitro over 2 d. The present results suggest that the pH induced micellization method due to the micelle-unimer transition of the pH sensitive block copolymer would be a novel and valuable drug incorporation tool for hydrophobic and protein drugs, since no organic solvent is involved in the formulation.
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