Effects on Goat Meat Extracts on α-Glucosidase Inhibitory Activity, Expression of Bcl-2-Associated X (BAX), p53, and p21 in Cell Line and Expression of Atrogin-1, Muscle Atrophy F-Box (MAFbx), Muscle RING-Finger Protein-1 (MuRF-1), and Myosin Heavy Chain-7 (MYH-7) in C2C12 Myoblsts
DC Field | Value | Language |
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dc.contributor.author | Kang, Joohyun | - |
dc.contributor.author | Kim, Soyeon | - |
dc.contributor.author | Lee, Yewon | - |
dc.contributor.author | Oh, Jei | - |
dc.contributor.author | Yoon, Yohan | - |
dc.date.accessioned | 2023-11-08T06:49:37Z | - |
dc.date.available | 2023-11-08T06:49:37Z | - |
dc.date.issued | 2023-03 | - |
dc.identifier.issn | 2636-0772 | - |
dc.identifier.issn | 2636-0780 | - |
dc.identifier.uri | https://scholarworks.sookmyung.ac.kr/handle/2020.sw.sookmyung/152015 | - |
dc.description.abstract | This study examined the α-glucosidase inhibitory, and apoptosis- and antimuscular- related factors of goat meat extracts from forelegs, hind legs, loin, and ribs. The goat meat extracts were evaluated for their α-glucosidase inhibitory activity. The gene and protein expression levels of Bcl-2-associated X (bax), p53, and p21 were examined by reverse transcription polymerase chain reaction (RT-PCR) and immunoblotting in AGS and HT-29 cells. The expression levels of Atrogin-1 and MHC1b were examined by RT-PCR in C2C12 myoblasts, and the expression levels of Atrogin-1, muscle atrophy F-box (MAFbx), muscle RING-finger protein-1 (MuRF-1), and myosin heavy chain-7 were investigated by immunoblotting. α-Glucosidase inhibitory activity was higher in ethanol extract than in hydrous and hot water extracts. BAX and p53 expression levels were higher (p<0.05) in AGS cells treated with goat meat extract than those of cells treated with no goat meat extract. In HT-29 cells, the protein expression levels of BAX, p53, and p21 were higher (p<0.05) in the cells treated with goat meat extract than those of cells not treated with goat meat extract. In dexamethasone-treated C2C12 cells, goat meat extract treatment lower (p<0.05) the expression of Atrogin-1 and lower (p<0.05) the expression of MAFbx and MuRF-1. The results of the present study indicate that goat meat extracts have α- glucosidase inhibitory activity in vitro. In addition, apoptosis was induced in AGS cells and HT-29 cells treated with goat meat extract, and anti-muscular atrophy activity was also observed in C2C12 cells treated with goat meat extract. | - |
dc.format.extent | 15 | - |
dc.language | 영어 | - |
dc.language.iso | ENG | - |
dc.publisher | 한국축산식품학회 | - |
dc.title | Effects on Goat Meat Extracts on α-Glucosidase Inhibitory Activity, Expression of Bcl-2-Associated X (BAX), p53, and p21 in Cell Line and Expression of Atrogin-1, Muscle Atrophy F-Box (MAFbx), Muscle RING-Finger Protein-1 (MuRF-1), and Myosin Heavy Chain-7 (MYH-7) in C2C12 Myoblsts | - |
dc.type | Article | - |
dc.publisher.location | 대한민국 | - |
dc.identifier.doi | 10.5851/kosfa.2023.e6 | - |
dc.identifier.scopusid | 2-s2.0-85153871617 | - |
dc.identifier.wosid | 000993423400010 | - |
dc.identifier.bibliographicCitation | 한국축산식품학회지, v.43, no.2, pp 359 - 373 | - |
dc.citation.title | 한국축산식품학회지 | - |
dc.citation.volume | 43 | - |
dc.citation.number | 2 | - |
dc.citation.startPage | 359 | - |
dc.citation.endPage | 373 | - |
dc.type.docType | Article | - |
dc.identifier.kciid | ART002933937 | - |
dc.description.isOpenAccess | N | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.description.journalRegisteredClass | kci | - |
dc.relation.journalResearchArea | Food Science & Technology | - |
dc.relation.journalWebOfScienceCategory | Food Science & Technology | - |
dc.subject.keywordPlus | SKELETAL-MUSCLE | - |
dc.subject.keywordPlus | MESSENGER-RNA | - |
dc.subject.keywordPlus | FIBER-TYPE | - |
dc.subject.keywordPlus | IN-VITRO | - |
dc.subject.keywordPlus | APOPTOSIS | - |
dc.subject.keywordPlus | ISOFORMS | - |
dc.subject.keywordPlus | PATHWAY | - |
dc.subject.keywordPlus | QUALITY | - |
dc.subject.keywordAuthor | goat meat | - |
dc.subject.keywordAuthor | extract | - |
dc.subject.keywordAuthor | α-glucosidase inhibitory activity | - |
dc.subject.keywordAuthor | apoptosis | - |
dc.subject.keywordAuthor | anti-muscular atrophy | - |
dc.identifier.url | https://www.kosfaj.org/archive/view_article?pid=kosfa-43-2-359 | - |
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