Luteolin inhibits LPS-stimulated inducible nitric oxide synthase expression in BV-2 microglial cells
- Authors
- Kim, JS; Lee, HJ; Lee, MH; Kim, J; Jin, C; Ryu, JH
- Issue Date
- Jan-2006
- Publisher
- GEORG THIEME VERLAG KG
- Citation
- PLANTA MEDICA, v.72, no.1, pp 65 - 68
- Pages
- 4
- Journal Title
- PLANTA MEDICA
- Volume
- 72
- Number
- 1
- Start Page
- 65
- End Page
- 68
- URI
- https://scholarworks.sookmyung.ac.kr/handle/2020.sw.sookmyung/15208
- DOI
- 10.1055/s-2005-873145
- ISSN
- 0032-0943
1439-0221
- Abstract
- Overproduction of nitric oxide (NO) by inducible nitric oxide synthase (iNOS) acts as a neurotoxic effector in the central nervous system, resulting in neurodegenerative diseases. From the alcoholic extracts of Perilla frutescens, we have purified an inhibitor of NO production in lipopolysaccharide (LPS)-activated microglia by activity-guided purification. The active compound was identified as luteolin by spectral analysis. Luteolin inhibited the NO production in LPS-activated microglia in a dose-dependent manner (IC50 = 6.9 mu M). Luteolin also suppressed the degradation of I-kappa B-alpha, the expression of protein and rnRNA of iNOS in LPS-activated microglia as observed in Western blot analysis and RT-PCR experiments. Luteolin may have beneficial effects in the treatment of neuro-inflammatory diseases through the inhibition of NOS expression.
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