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Transcriptional programming of pathogenic genes in polycystic kidney disease
- Authors
- Ko, Je Yeong; Park, Jong Hoon
- Issue Date
- Jan-2023
- Publisher
- Elsevier B.V.
- Citation
- Kidney International, v.103, no.1, pp 25 - 28
- Pages
- 4
- Journal Title
- Kidney International
- Volume
- 103
- Number
- 1
- Start Page
- 25
- End Page
- 28
- ISSN
- 0085-2538
1523-1755
- Abstract
- Transcriptional dysregulation is a prominent contributor to the pathogenesis of autosomal dominant polycystic kidney disease. Lakhia et al. identified an enhancer landscape associated with disease genes and its pathologic role in autosomal dominant polycystic kidney disease to understand cyst formation. This commentary discusses these findings reported by Lakhia et al. in the broader contexts of transcriptional programming and the identification of potential autosomal dominant polycystic kidney disease therapeutic targets. © 2022 International Society of Nephrology
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