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Comparative transcriptome and metabolome analyses of four Panax species explore the dynamics of metabolite biosynthesisopen access

Authors
Koo, HyunjinLee, Yun SunNguyen, Van BinhGiang, Vo Ngoc LinhKoo, Hyun JoPark, Hyun-SeungMohanan, PadmanabanSong, Young HunRyu, ByeolKang, Kyo BinSung, Sang HyunYang, Tae-Jin
Issue Date
Jan-2023
Publisher
The Korean Society of Ginseng
Keywords
Adventitious root; De novo assembly; Oxidosqualene cyclase; Panax species; Specialized metabolite profiling
Citation
Journal of Ginseng Research, v.47, no.1, pp 44 - 53
Pages
10
Journal Title
Journal of Ginseng Research
Volume
47
Number
1
Start Page
44
End Page
53
URI
https://scholarworks.sookmyung.ac.kr/handle/2020.sw.sookmyung/152124
DOI
10.1016/j.jgr.2022.07.001
ISSN
1226-8453
2093-4947
Abstract
Background: The genus Panax in the Araliaceae family has been used as traditional medicinal plants worldwide and is known to biosynthesize ginsenosides and phytosterols. However, genetic variation between Panax species has influenced their biosynthetic pathways is not fully understood. Methods: Simultaneous analysis of transcriptomes and metabolomes obtained from adventitious roots of two tetraploid species (Panax ginseng and P. quinquefolius) and two diploid species (P. notoginseng and P. vietnamensis) revealed the diversity of their metabolites and related gene expression profiles. Results: The transcriptome analysis showed that 2,3-OXIDOSQUALENE CYCLASEs (OSCs) involved in phytosterol biosynthesis are upregulated in the diploid species, while the expression of OSCs contributing to ginsenoside biosynthesis is higher in the tetraploid species. In agreement with these results, the contents of dammarenediol-type ginsenosides were higher in the tetraploid species relative to the diploid species. Conclusion: These results suggest that a whole-genome duplication event has influenced the triterpene biosynthesis pathway in tetraploid Panax species during their evolution or ecological adaptation. This study provides a basis for further efforts to explore the genetic variation of the Panax genus. © 2022
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